Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
msrABPeptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity). (356 aa)    
Predicted Functional Partners:
AMQ93357.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.999
dsbD
Thiol:disulfide interchange protein; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily.
   
 
 0.974
AMQ93356.1
Cytochrome C biogenesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.970
AMQ93294.1
Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.956
AMQ93586.1
Disulfide bond formation protein DsbE; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.956
AMQ93596.1
Thiol:disulfide interchange protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.956
AMQ94112.1
Glutathione peroxidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.838
AMQ94587.1
Catalase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the catalase family.
   
 
 0.794
AMQ93303.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.734
thrA
Aspartate kinase; Multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.732
Your Current Organism:
Aggregatibacter actinomycetemcomitans
NCBI taxonomy Id: 714
Other names: A. actinomycetemcomitans, ATCC 33384, Actinobacillus (Haemophilus) actinomycetemcomitans, Actinobacillus actinomycetemcomitans, Bacterium acetinomycetum comitans, Bacterium actinomycetem comitans, Bacterium comitans, CCUG 13227, CIP 52.106, DSM 8324, Haemophilus actinomycetemcomitans, Haemophilus actinomyceticomitans, NCTC 9710
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.