Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AMQ93381.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (203 aa)    
Predicted Functional Partners:
cca
2', 3'-cyclic nucleotide 2'-phosphodiesterase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
 
  
 0.952
lolB
Outer membrane lipoprotein LolB; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
 
     0.652
AMQ93916.1
Tubulin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.649
AMQ93380.1
Phosphate permease; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.641
AMQ95136.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.637
ispE
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
       0.605
AMQ93379.1
Phosphate transport regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.592
uspA
Universal stress protein; Required for resistance to DNA-damaging agents. Belongs to the universal stress protein A family.
 
    0.573
AMQ93909.1
Heme biosynthesis protein HemY; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.551
yceD
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.528
Your Current Organism:
Aggregatibacter actinomycetemcomitans
NCBI taxonomy Id: 714
Other names: A. actinomycetemcomitans, ATCC 33384, Actinobacillus (Haemophilus) actinomycetemcomitans, Actinobacillus actinomycetemcomitans, Bacterium acetinomycetum comitans, Bacterium actinomycetem comitans, Bacterium comitans, CCUG 13227, CIP 52.106, DSM 8324, Haemophilus actinomycetemcomitans, Haemophilus actinomyceticomitans, NCTC 9710
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