STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
emrBMultidrug resistance protein B; Multidrug MFS transporte; with EmrA is involved in resistance to hydrophobic antibiotics such as nalidixic acid; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the major facilitator superfamily. (505 aa)    
Predicted Functional Partners:
AMQ93844.1
Multidrug transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.684
rsmA
rRNA methyltransferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
   
  
 0.640
macB
Macrolide transporter; Part of the tripartite efflux system MacAB-TdeA. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides; Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
   
 
 0.566
AMQ93603.1
Bicyclomycin/multidrug efflux system; Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.496
AMQ93433.1
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.480
parC
DNA topoisomerase IV; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
      
 0.427
glpT
Catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.426
lapA
Hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family.
      
 0.420
folA
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
    
 
 0.413
tdeA
Hypothetical protein; Required for secretion of the LtxA leukotoxin and resistance to various antimicrobial compounds.
 
 
 0.411
Your Current Organism:
Aggregatibacter actinomycetemcomitans
NCBI taxonomy Id: 714
Other names: A. actinomycetemcomitans, ATCC 33384, Actinobacillus (Haemophilus) actinomycetemcomitans, Actinobacillus actinomycetemcomitans, Bacterium acetinomycetum comitans, Bacterium actinomycetem comitans, Bacterium comitans, CCUG 13227, CIP 52.106, DSM 8324, Haemophilus actinomycetemcomitans, Haemophilus actinomyceticomitans, NCTC 9710
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