lptA protein (Aggregatibacter actinomycetemcomitans)

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lptA

Lipopolysaccharide transport periplasmic protein LptA; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm. (172 aa)

Predicted Functional Partners:

lptC

0.997

lptB

0.990

lptD

0.959

ptsN

0.819

lptE

0.789

bamE

0.767

AMQ93510.1

0.756

lptG

0.699

lptF

0.670

lolA

0.656

Your Current Organism:

Aggregatibacter actinomycetemcomitans

NCBI taxonomy Id: 714
Other names: A. actinomycetemcomitans, ATCC 33384, Actinobacillus (Haemophilus) actinomycetemcomitans, Actinobacillus actinomycetemcomitans, Bacterium acetinomycetum comitans, Bacterium actinomycetem comitans, Bacterium comitans, CCUG 13227, CIP 52.106, DSM 8324, Haemophilus actinomycetemcomitans, Haemophilus actinomyceticomitans, NCTC 9710

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMQ93510.1	lptA	ACT75_02750	ACT75_02765	glmZ(sRNA)-inactivating NTPase; Displays ATPase and GTPase activities.	Lipopolysaccharide transport periplasmic protein LptA; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.	0.756
AMQ93510.1	lptB	ACT75_02750	ACT75_02760	glmZ(sRNA)-inactivating NTPase; Displays ATPase and GTPase activities.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.739
AMQ93510.1	lptC	ACT75_02750	ACT75_02770	glmZ(sRNA)-inactivating NTPase; Displays ATPase and GTPase activities.	LPS export ABC transporter periplasmic protein LptC; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family.	0.735
AMQ93510.1	ptsN	ACT75_02750	ACT75_02755	glmZ(sRNA)-inactivating NTPase; Displays ATPase and GTPase activities.	PTS sugar transporter subunit IIA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.917
bamE	lolA	ACT75_05075	ACT75_09875	Cell envelope protein SmpA; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.	Outer membrane lipoprotein carrier protein LolA; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).	0.453
bamE	lptA	ACT75_05075	ACT75_02765	Cell envelope protein SmpA; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.	Lipopolysaccharide transport periplasmic protein LptA; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.	0.767
bamE	lptD	ACT75_05075	ACT75_04495	Cell envelope protein SmpA; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.	LPS biosynthesis protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.	0.819
bamE	lptE	ACT75_05075	ACT75_05580	Cell envelope protein SmpA; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.	Hypothetical protein; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.	0.552
lolA	bamE	ACT75_09875	ACT75_05075	Outer membrane lipoprotein carrier protein LolA; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).	Cell envelope protein SmpA; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.	0.453
lolA	lptA	ACT75_09875	ACT75_02765	Outer membrane lipoprotein carrier protein LolA; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).	Lipopolysaccharide transport periplasmic protein LptA; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.	0.656
lolA	lptC	ACT75_09875	ACT75_02770	Outer membrane lipoprotein carrier protein LolA; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).	LPS export ABC transporter periplasmic protein LptC; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family.	0.556
lolA	lptD	ACT75_09875	ACT75_04495	Outer membrane lipoprotein carrier protein LolA; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).	LPS biosynthesis protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.	0.771
lolA	lptE	ACT75_09875	ACT75_05580	Outer membrane lipoprotein carrier protein LolA; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).	Hypothetical protein; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.	0.707
lolA	lptF	ACT75_09875	ACT75_00990	Outer membrane lipoprotein carrier protein LolA; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).	LPS export ABC transporter permease LptF; With LptBGC is involved in lipopolysaccharide export; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.469
lptA	AMQ93510.1	ACT75_02765	ACT75_02750	Lipopolysaccharide transport periplasmic protein LptA; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.	glmZ(sRNA)-inactivating NTPase; Displays ATPase and GTPase activities.	0.756
lptA	bamE	ACT75_02765	ACT75_05075	Lipopolysaccharide transport periplasmic protein LptA; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.	Cell envelope protein SmpA; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.	0.767
lptA	lolA	ACT75_02765	ACT75_09875	Lipopolysaccharide transport periplasmic protein LptA; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.	Outer membrane lipoprotein carrier protein LolA; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).	0.656
lptA	lptB	ACT75_02765	ACT75_02760	Lipopolysaccharide transport periplasmic protein LptA; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.990
lptA	lptC	ACT75_02765	ACT75_02770	Lipopolysaccharide transport periplasmic protein LptA; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.	LPS export ABC transporter periplasmic protein LptC; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family.	0.997
lptA	lptD	ACT75_02765	ACT75_04495	Lipopolysaccharide transport periplasmic protein LptA; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.	LPS biosynthesis protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.	0.959

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