Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mlaDOuter membrane lipid asymmetry maintenance protein MlaD; Derived by automated computational analysis using gene prediction method: Protein Homology. (169 aa)    
Predicted Functional Partners:
mlaF
ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.999
mlaE
ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.
 0.999
mlaC
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 0.999
AMQ93519.1
Anti-anti-sigma factor; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.958
AMQ94063.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.815
AMQ93520.1
BolA family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the BolA/IbaG family.
     
 0.612
lptF
LPS export ABC transporter permease LptF; With LptBGC is involved in lipopolysaccharide export; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   
 0.576
lptB
ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.546
murA
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.
       0.530
macB
Macrolide transporter; Part of the tripartite efflux system MacAB-TdeA. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides; Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
     
 0.522
Your Current Organism:
Aggregatibacter actinomycetemcomitans
NCBI taxonomy Id: 714
Other names: A. actinomycetemcomitans, ATCC 33384, Actinobacillus (Haemophilus) actinomycetemcomitans, Actinobacillus actinomycetemcomitans, Bacterium acetinomycetum comitans, Bacterium actinomycetem comitans, Bacterium comitans, CCUG 13227, CIP 52.106, DSM 8324, Haemophilus actinomycetemcomitans, Haemophilus actinomyceticomitans, NCTC 9710
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