Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cpxAHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)    
Predicted Functional Partners:
AMQ93938.1
Response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; Derived by automated computational analysis using gene prediction method: Protein Homology.
 0.995
arcA
Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.842
AMQ94436.1
ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 
0.836
AMQ93167.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.783
napA
Nitrate reductase; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
      
 0.678
AMQ93168.1
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.645
bamE
Cell envelope protein SmpA; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
       0.531
narL
Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 
 0.499
mukB
Cell division protein MukB; Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division; Belongs to the SMC family. MukB subfamily.
  
     0.490
AMQ93108.1
Fis family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.457
Your Current Organism:
Aggregatibacter actinomycetemcomitans
NCBI taxonomy Id: 714
Other names: A. actinomycetemcomitans, ATCC 33384, Actinobacillus (Haemophilus) actinomycetemcomitans, Actinobacillus actinomycetemcomitans, Bacterium acetinomycetum comitans, Bacterium actinomycetem comitans, Bacterium comitans, CCUG 13227, CIP 52.106, DSM 8324, Haemophilus actinomycetemcomitans, Haemophilus actinomyceticomitans, NCTC 9710
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