STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ltxCHemolysin D; Required for full activity and modification of the LtxA leukotoxin. Involved in fatty acid modification of the protoxin at two internal lysine residues, thereby converting it to the active toxin. Belongs to the RTX toxin acyltransferase family. (168 aa)    
Predicted Functional Partners:
ltxA
Hemolysin; Virulence factor that plays an important role in immune evasion. Lyses human lymphocytes and monocytes. Binds to the LFA-1 integrin on the surface of the host cell and to cholesterol-containing membranes, which probably results in large LtxA-LFA-1 clusters in lipid rafts. Shows also beta-hemolytic activity on certain types of growth media.
 
   
 0.978
ltxB
Peptidase C39; Involved in the export of the LtxA leukotoxin. Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family.
 
   
 0.953
ltxD
Hemolysin D; Involved in the export of the LtxA leukotoxin.
 
   
 0.938
AMQ95076.1
Ligand-gated channel; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.772
AMQ94712.1
TonB-dependent receptor; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.678
tdeA
Hypothetical protein; Required for secretion of the LtxA leukotoxin and resistance to various antimicrobial compounds.
      
 0.618
AMQ93403.1
Chemotaxis protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.606
AMQ93059.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.536
AMQ93992.1
Lipooligosaccharide biosynthesis protein lex-1; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.531
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.491
Your Current Organism:
Aggregatibacter actinomycetemcomitans
NCBI taxonomy Id: 714
Other names: A. actinomycetemcomitans, ATCC 33384, Actinobacillus (Haemophilus) actinomycetemcomitans, Actinobacillus actinomycetemcomitans, Bacterium acetinomycetum comitans, Bacterium actinomycetem comitans, Bacterium comitans, CCUG 13227, CIP 52.106, DSM 8324, Haemophilus actinomycetemcomitans, Haemophilus actinomyceticomitans, NCTC 9710
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