node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMQ93807.1 | ltxB | ACT75_04335 | ACT75_09610 | Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Peptidase C39; Involved in the export of the LtxA leukotoxin. Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family. | 0.654 |
AMQ94436.1 | ltxA | ACT75_07835 | ACT75_09605 | ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hemolysin; Virulence factor that plays an important role in immune evasion. Lyses human lymphocytes and monocytes. Binds to the LFA-1 integrin on the surface of the host cell and to cholesterol-containing membranes, which probably results in large LtxA-LFA-1 clusters in lipid rafts. Shows also beta-hemolytic activity on certain types of growth media. | 0.561 |
AMQ94436.1 | ltxB | ACT75_07835 | ACT75_09610 | ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Peptidase C39; Involved in the export of the LtxA leukotoxin. Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family. | 0.443 |
AMQ94436.1 | ltxD | ACT75_07835 | ACT75_09615 | ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hemolysin D; Involved in the export of the LtxA leukotoxin. | 0.597 |
AMQ94436.1 | tdeA | ACT75_07835 | ACT75_10870 | ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Required for secretion of the LtxA leukotoxin and resistance to various antimicrobial compounds. | 0.447 |
cydC | ltxB | ACT75_06000 | ACT75_09610 | ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Peptidase C39; Involved in the export of the LtxA leukotoxin. Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family. | 0.638 |
ltxA | AMQ94436.1 | ACT75_09605 | ACT75_07835 | Hemolysin; Virulence factor that plays an important role in immune evasion. Lyses human lymphocytes and monocytes. Binds to the LFA-1 integrin on the surface of the host cell and to cholesterol-containing membranes, which probably results in large LtxA-LFA-1 clusters in lipid rafts. Shows also beta-hemolytic activity on certain types of growth media. | ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.561 |
ltxA | ltxB | ACT75_09605 | ACT75_09610 | Hemolysin; Virulence factor that plays an important role in immune evasion. Lyses human lymphocytes and monocytes. Binds to the LFA-1 integrin on the surface of the host cell and to cholesterol-containing membranes, which probably results in large LtxA-LFA-1 clusters in lipid rafts. Shows also beta-hemolytic activity on certain types of growth media. | Peptidase C39; Involved in the export of the LtxA leukotoxin. Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family. | 0.983 |
ltxA | ltxC | ACT75_09605 | ACT75_09600 | Hemolysin; Virulence factor that plays an important role in immune evasion. Lyses human lymphocytes and monocytes. Binds to the LFA-1 integrin on the surface of the host cell and to cholesterol-containing membranes, which probably results in large LtxA-LFA-1 clusters in lipid rafts. Shows also beta-hemolytic activity on certain types of growth media. | Hemolysin D; Required for full activity and modification of the LtxA leukotoxin. Involved in fatty acid modification of the protoxin at two internal lysine residues, thereby converting it to the active toxin. Belongs to the RTX toxin acyltransferase family. | 0.978 |
ltxA | ltxD | ACT75_09605 | ACT75_09615 | Hemolysin; Virulence factor that plays an important role in immune evasion. Lyses human lymphocytes and monocytes. Binds to the LFA-1 integrin on the surface of the host cell and to cholesterol-containing membranes, which probably results in large LtxA-LFA-1 clusters in lipid rafts. Shows also beta-hemolytic activity on certain types of growth media. | Hemolysin D; Involved in the export of the LtxA leukotoxin. | 0.973 |
ltxA | tdeA | ACT75_09605 | ACT75_10870 | Hemolysin; Virulence factor that plays an important role in immune evasion. Lyses human lymphocytes and monocytes. Binds to the LFA-1 integrin on the surface of the host cell and to cholesterol-containing membranes, which probably results in large LtxA-LFA-1 clusters in lipid rafts. Shows also beta-hemolytic activity on certain types of growth media. | Hypothetical protein; Required for secretion of the LtxA leukotoxin and resistance to various antimicrobial compounds. | 0.686 |
ltxB | AMQ93807.1 | ACT75_09610 | ACT75_04335 | Peptidase C39; Involved in the export of the LtxA leukotoxin. Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family. | Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.654 |
ltxB | AMQ94436.1 | ACT75_09610 | ACT75_07835 | Peptidase C39; Involved in the export of the LtxA leukotoxin. Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family. | ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.443 |
ltxB | cydC | ACT75_09610 | ACT75_06000 | Peptidase C39; Involved in the export of the LtxA leukotoxin. Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family. | ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.638 |
ltxB | ltxA | ACT75_09610 | ACT75_09605 | Peptidase C39; Involved in the export of the LtxA leukotoxin. Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family. | Hemolysin; Virulence factor that plays an important role in immune evasion. Lyses human lymphocytes and monocytes. Binds to the LFA-1 integrin on the surface of the host cell and to cholesterol-containing membranes, which probably results in large LtxA-LFA-1 clusters in lipid rafts. Shows also beta-hemolytic activity on certain types of growth media. | 0.983 |
ltxB | ltxC | ACT75_09610 | ACT75_09600 | Peptidase C39; Involved in the export of the LtxA leukotoxin. Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family. | Hemolysin D; Required for full activity and modification of the LtxA leukotoxin. Involved in fatty acid modification of the protoxin at two internal lysine residues, thereby converting it to the active toxin. Belongs to the RTX toxin acyltransferase family. | 0.953 |
ltxB | ltxD | ACT75_09610 | ACT75_09615 | Peptidase C39; Involved in the export of the LtxA leukotoxin. Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family. | Hemolysin D; Involved in the export of the LtxA leukotoxin. | 0.996 |
ltxB | msbA | ACT75_09610 | ACT75_01290 | Peptidase C39; Involved in the export of the LtxA leukotoxin. Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family. | Lipid transporter ATP-binding/permease; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. | 0.686 |
ltxB | tdeA | ACT75_09610 | ACT75_10870 | Peptidase C39; Involved in the export of the LtxA leukotoxin. Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family. | Hypothetical protein; Required for secretion of the LtxA leukotoxin and resistance to various antimicrobial compounds. | 0.829 |
ltxC | ltxA | ACT75_09600 | ACT75_09605 | Hemolysin D; Required for full activity and modification of the LtxA leukotoxin. Involved in fatty acid modification of the protoxin at two internal lysine residues, thereby converting it to the active toxin. Belongs to the RTX toxin acyltransferase family. | Hemolysin; Virulence factor that plays an important role in immune evasion. Lyses human lymphocytes and monocytes. Binds to the LFA-1 integrin on the surface of the host cell and to cholesterol-containing membranes, which probably results in large LtxA-LFA-1 clusters in lipid rafts. Shows also beta-hemolytic activity on certain types of growth media. | 0.978 |