STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ltxDHemolysin D; Involved in the export of the LtxA leukotoxin. (477 aa)    
Predicted Functional Partners:
ltxB
Peptidase C39; Involved in the export of the LtxA leukotoxin. Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family.
 
 0.997
ltxA
Hemolysin; Virulence factor that plays an important role in immune evasion. Lyses human lymphocytes and monocytes. Binds to the LFA-1 integrin on the surface of the host cell and to cholesterol-containing membranes, which probably results in large LtxA-LFA-1 clusters in lipid rafts. Shows also beta-hemolytic activity on certain types of growth media.
 
  
 0.977
ltxC
Hemolysin D; Required for full activity and modification of the LtxA leukotoxin. Involved in fatty acid modification of the protoxin at two internal lysine residues, thereby converting it to the active toxin. Belongs to the RTX toxin acyltransferase family.
 
   
 0.942
tdeA
Hypothetical protein; Required for secretion of the LtxA leukotoxin and resistance to various antimicrobial compounds.
  
 
 0.912
macB
Macrolide transporter; Part of the tripartite efflux system MacAB-TdeA. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides; Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
  
  
 0.822
AMQ95096.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
 
 
 0.772
AMQ93291.1
ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.667
AMQ94436.1
ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.655
AMQ93029.1
Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.645
AMQ93529.1
Adhesin; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.524
Your Current Organism:
Aggregatibacter actinomycetemcomitans
NCBI taxonomy Id: 714
Other names: A. actinomycetemcomitans, ATCC 33384, Actinobacillus (Haemophilus) actinomycetemcomitans, Actinobacillus actinomycetemcomitans, Bacterium acetinomycetum comitans, Bacterium actinomycetem comitans, Bacterium comitans, CCUG 13227, CIP 52.106, DSM 8324, Haemophilus actinomycetemcomitans, Haemophilus actinomyceticomitans, NCTC 9710
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