STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cdtBCytolethal distending toxin subunit CdtB; Cdt from Campylobacter forms the A subunit (CdtB) that is delivered into host cells by the heterologous B subnit (CdtA/C); in Salmonella, CdtB alone is encoded; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)    
Predicted Functional Partners:
cdtA
Cytochrome C oxidase subunit I; CDTs are cytotoxins which induce host cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells.
  
 
 0.999
cdtC
Cytochrome C oxidase subunit I; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.999
vppA
Virulence protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.874
AMQ95041.1
Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
   0.748
AMQ94930.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.737
ltxA
Hemolysin; Virulence factor that plays an important role in immune evasion. Lyses human lymphocytes and monocytes. Binds to the LFA-1 integrin on the surface of the host cell and to cholesterol-containing membranes, which probably results in large LtxA-LFA-1 clusters in lipid rafts. Shows also beta-hemolytic activity on certain types of growth media.
      
 0.618
apaH
Diadenosine tetraphosphatase; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family.
   
  
 0.612
AMQ94927.1
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.524
AMQ94928.1
MazF family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.524
ompA
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the outer membrane OOP (TC 1.B.6) superfamily.
   
  
 0.472
Your Current Organism:
Aggregatibacter actinomycetemcomitans
NCBI taxonomy Id: 714
Other names: A. actinomycetemcomitans, ATCC 33384, Actinobacillus (Haemophilus) actinomycetemcomitans, Actinobacillus actinomycetemcomitans, Bacterium acetinomycetum comitans, Bacterium actinomycetem comitans, Bacterium comitans, CCUG 13227, CIP 52.106, DSM 8324, Haemophilus actinomycetemcomitans, Haemophilus actinomyceticomitans, NCTC 9710
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