Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
lsrBAutoinducer 2-binding protein lsrB; With lsrACD is involved in the transport of autoinducer 2 into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology. (351 aa)    
Predicted Functional Partners:
lsrF
Involved in autoinducer 2 transport and processing; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.998
lsrG
Autoinducer-2 (AI-2) modifying protein LsrG; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.997
AMQ95066.1
With IsrABC is involved with autoinducer 2 import; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the binding-protein-dependent transport system permease family.
 0.996
AMQ95189.1
ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.
 0.994
lsrA
ABC transporter ATP-binding protein; With LsrCDB is involved in the transport of autoindiuce 2; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.985
lsrR
Transcriptional regulator LsrR; Regulates the transcription of lsr genes; involved in autoinducer 2 uptake, biofilm formation and stress responses; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.964
AMQ94436.1
ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.952
lsrK
Autoinducer kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.946
luxS
S-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
      
 0.738
rbsC
Ribose ABC transporter permease; Functions to transport ribose at high affinity; forms a complex with RbsA2C2B; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the binding-protein-dependent transport system permease family.
 
 
 
 0.705
Your Current Organism:
Aggregatibacter actinomycetemcomitans
NCBI taxonomy Id: 714
Other names: A. actinomycetemcomitans, ATCC 33384, Actinobacillus (Haemophilus) actinomycetemcomitans, Actinobacillus actinomycetemcomitans, Bacterium acetinomycetum comitans, Bacterium actinomycetem comitans, Bacterium comitans, CCUG 13227, CIP 52.106, DSM 8324, Haemophilus actinomycetemcomitans, Haemophilus actinomyceticomitans, NCTC 9710
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