STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AMQ95076.1Ligand-gated channel; Derived by automated computational analysis using gene prediction method: Protein Homology. (814 aa)    
Predicted Functional Partners:
AMQ95075.1
Transferrin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.794
AMQ94712.1
TonB-dependent receptor; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.786
ltxC
Hemolysin D; Required for full activity and modification of the LtxA leukotoxin. Involved in fatty acid modification of the protoxin at two internal lysine residues, thereby converting it to the active toxin. Belongs to the RTX toxin acyltransferase family.
  
     0.772
AMQ93992.1
Lipooligosaccharide biosynthesis protein lex-1; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.726
AMQ93059.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.710
AMQ93035.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.692
ltxA
Hemolysin; Virulence factor that plays an important role in immune evasion. Lyses human lymphocytes and monocytes. Binds to the LFA-1 integrin on the surface of the host cell and to cholesterol-containing membranes, which probably results in large LtxA-LFA-1 clusters in lipid rafts. Shows also beta-hemolytic activity on certain types of growth media.
  
     0.652
yccS
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.583
AMQ94978.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.508
AMQ93622.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 
 0.479
Your Current Organism:
Aggregatibacter actinomycetemcomitans
NCBI taxonomy Id: 714
Other names: A. actinomycetemcomitans, ATCC 33384, Actinobacillus (Haemophilus) actinomycetemcomitans, Actinobacillus actinomycetemcomitans, Bacterium acetinomycetum comitans, Bacterium actinomycetem comitans, Bacterium comitans, CCUG 13227, CIP 52.106, DSM 8324, Haemophilus actinomycetemcomitans, Haemophilus actinomyceticomitans, NCTC 9710
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