| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| lepA | lepB | HI_0016 | HI_0015 | GTP-binding membrane protein (lepA); Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | Signal peptidase I (lepB); Similar to GB:K00426 SP:P00803 PID:146600 PID:987643 GB:U00096 percent identity: 46.31; identified by sequence similarity; putative; Belongs to the peptidase S26 family. | 0.980 |
| lepA | rnc | HI_0016 | HI_0014 | GTP-binding membrane protein (lepA); Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | Ribonuclease III (rnc); Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. | 0.911 |
| lepA | rplB | HI_0016 | HI_0780 | GTP-binding membrane protein (lepA); Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | Ribosomal protein L2 (rpL2); One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | 0.935 |
| lepA | rplM | HI_0016 | HI_1443 | GTP-binding membrane protein (lepA); Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | Ribosomal protein L13 (rpL13); This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 0.952 |
| lepA | rplO | HI_0016 | HI_0797 | GTP-binding membrane protein (lepA); Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | Ribosomal protein L15 (rpL15); Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. | 0.917 |
| lepA | rpmF | HI_0016 | HI_0158 | GTP-binding membrane protein (lepA); Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | Ribosomal protein L32 (rpL32); Similar to GB:M29698 SP:P02435 PID:147712 GB:U00096 PID:1651531 percent identity: 77.19; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL32 family. | 0.912 |
| lepA | rpsB | HI_0016 | HI_0913 | GTP-binding membrane protein (lepA); Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | Ribosomal protein S2 (rpS2); Similar to GB:D26562 SP:P02351 GB:V00343 PID:42842 PID:473824 percent identity: 82.16; identified by sequence similarity; putative; Belongs to the universal ribosomal protein uS2 family. | 0.934 |
| lepA | rpsD | HI_0016 | HI_0801 | GTP-binding membrane protein (lepA); Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | Ribosomal protein S4 (rpS4); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. | 0.935 |
| lepA | rpsI | HI_0016 | HI_1442 | GTP-binding membrane protein (lepA); Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | Ribosomal protein S9 (rpS9); Similar to GB:S75161 SP:P31782 PID:241867 percent identity: 94.62; identified by sequence similarity; putative; Belongs to the universal ribosomal protein uS9 family. | 0.929 |
| lepA | rpsL | HI_0016 | HI_0581 | GTP-binding membrane protein (lepA); Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | Ribosomal protein S12 (rps12); With S4 and S5 plays an important role in translational accuracy. | 0.926 |
| lepB | lepA | HI_0015 | HI_0016 | Signal peptidase I (lepB); Similar to GB:K00426 SP:P00803 PID:146600 PID:987643 GB:U00096 percent identity: 46.31; identified by sequence similarity; putative; Belongs to the peptidase S26 family. | GTP-binding membrane protein (lepA); Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 0.980 |
| lepB | rnc | HI_0015 | HI_0014 | Signal peptidase I (lepB); Similar to GB:K00426 SP:P00803 PID:146600 PID:987643 GB:U00096 percent identity: 46.31; identified by sequence similarity; putative; Belongs to the peptidase S26 family. | Ribonuclease III (rnc); Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. | 0.923 |
| lepB | rpmF | HI_0015 | HI_0158 | Signal peptidase I (lepB); Similar to GB:K00426 SP:P00803 PID:146600 PID:987643 GB:U00096 percent identity: 46.31; identified by sequence similarity; putative; Belongs to the peptidase S26 family. | Ribosomal protein L32 (rpL32); Similar to GB:M29698 SP:P02435 PID:147712 GB:U00096 PID:1651531 percent identity: 77.19; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL32 family. | 0.452 |
| rnc | lepA | HI_0014 | HI_0016 | Ribonuclease III (rnc); Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. | GTP-binding membrane protein (lepA); Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 0.911 |
| rnc | lepB | HI_0014 | HI_0015 | Ribonuclease III (rnc); Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. | Signal peptidase I (lepB); Similar to GB:K00426 SP:P00803 PID:146600 PID:987643 GB:U00096 percent identity: 46.31; identified by sequence similarity; putative; Belongs to the peptidase S26 family. | 0.923 |
| rnc | rplB | HI_0014 | HI_0780 | Ribonuclease III (rnc); Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. | Ribosomal protein L2 (rpL2); One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | 0.796 |
| rnc | rplM | HI_0014 | HI_1443 | Ribonuclease III (rnc); Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. | Ribosomal protein L13 (rpL13); This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 0.836 |
| rnc | rplO | HI_0014 | HI_0797 | Ribonuclease III (rnc); Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. | Ribosomal protein L15 (rpL15); Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. | 0.818 |
| rnc | rpmF | HI_0014 | HI_0158 | Ribonuclease III (rnc); Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. | Ribosomal protein L32 (rpL32); Similar to GB:M29698 SP:P02435 PID:147712 GB:U00096 PID:1651531 percent identity: 77.19; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL32 family. | 0.846 |
| rnc | rpsB | HI_0014 | HI_0913 | Ribonuclease III (rnc); Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. | Ribosomal protein S2 (rpS2); Similar to GB:D26562 SP:P02351 GB:V00343 PID:42842 PID:473824 percent identity: 82.16; identified by sequence similarity; putative; Belongs to the universal ribosomal protein uS2 family. | 0.812 |
