node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HI_0028 | dacA | HI_0028 | HI_0029 | Conserved hypothetical protein; Similar to GB:L07636 SP:P30977 PID:146621 GB:U00096 PID:1778548 percent identity: 50.59; identified by sequence similarity; putative; Belongs to the UPF0250 family. | Penicillin-binding protein 5 (dacA); Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; Belongs to the peptidase S11 family. | 0.629 |
HI_0028 | lipB | HI_0028 | HI_0027 | Conserved hypothetical protein; Similar to GB:L07636 SP:P30977 PID:146621 GB:U00096 PID:1778548 percent identity: 50.59; identified by sequence similarity; putative; Belongs to the UPF0250 family. | Lipoate biosynthesis protein B (lipB); Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.849 |
HI_0028 | mrdA | HI_0028 | HI_0032 | Conserved hypothetical protein; Similar to GB:L07636 SP:P30977 PID:146621 GB:U00096 PID:1778548 percent identity: 50.59; identified by sequence similarity; putative; Belongs to the UPF0250 family. | Penicillin-binding protein 2 (pbp2); Catalyzes cross-linking of the peptidoglycan cell wall. | 0.518 |
HI_0028 | mrdB | HI_0028 | HI_0031 | Conserved hypothetical protein; Similar to GB:L07636 SP:P30977 PID:146621 GB:U00096 PID:1778548 percent identity: 50.59; identified by sequence similarity; putative; Belongs to the UPF0250 family. | Rod shape-determining protein (rodA); Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | 0.518 |
HI_0028 | rlmH | HI_0028 | HI_0033 | Conserved hypothetical protein; Similar to GB:L07636 SP:P30977 PID:146621 GB:U00096 PID:1778548 percent identity: 50.59; identified by sequence similarity; putative; Belongs to the UPF0250 family. | Conserved hypothetical protein; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. | 0.492 |
HI_0028 | rlpA | HI_0028 | HI_0030 | Conserved hypothetical protein; Similar to GB:L07636 SP:P30977 PID:146621 GB:U00096 PID:1778548 percent identity: 50.59; identified by sequence similarity; putative; Belongs to the UPF0250 family. | Lipoprotein, putative; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. | 0.623 |
dacA | HI_0028 | HI_0029 | HI_0028 | Penicillin-binding protein 5 (dacA); Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; Belongs to the peptidase S11 family. | Conserved hypothetical protein; Similar to GB:L07636 SP:P30977 PID:146621 GB:U00096 PID:1778548 percent identity: 50.59; identified by sequence similarity; putative; Belongs to the UPF0250 family. | 0.629 |
dacA | dacB | HI_0029 | HI_1330 | Penicillin-binding protein 5 (dacA); Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; Belongs to the peptidase S11 family. | D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase (dacB); Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction; Belongs to the peptidase S13 family. | 0.833 |
dacA | ftsI | HI_0029 | HI_1132 | Penicillin-binding protein 5 (dacA); Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; Belongs to the peptidase S11 family. | Penicillin-binding protein 3 (ftsI); Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | 0.655 |
dacA | lipB | HI_0029 | HI_0027 | Penicillin-binding protein 5 (dacA); Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; Belongs to the peptidase S11 family. | Lipoate biosynthesis protein B (lipB); Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.616 |
dacA | mrcA | HI_0029 | HI_0440 | Penicillin-binding protein 5 (dacA); Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; Belongs to the peptidase S11 family. | Penicillin-binding protein 1A (ponA); Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | 0.735 |
dacA | mrcB | HI_0029 | HI_1725 | Penicillin-binding protein 5 (dacA); Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; Belongs to the peptidase S11 family. | Penicillin-binding protein 1B (ponB); Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits) (By similarity). | 0.640 |
dacA | mrdA | HI_0029 | HI_0032 | Penicillin-binding protein 5 (dacA); Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; Belongs to the peptidase S11 family. | Penicillin-binding protein 2 (pbp2); Catalyzes cross-linking of the peptidoglycan cell wall. | 0.807 |
dacA | mrdB | HI_0029 | HI_0031 | Penicillin-binding protein 5 (dacA); Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; Belongs to the peptidase S11 family. | Rod shape-determining protein (rodA); Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | 0.720 |
dacA | rlmH | HI_0029 | HI_0033 | Penicillin-binding protein 5 (dacA); Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; Belongs to the peptidase S11 family. | Conserved hypothetical protein; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. | 0.643 |
dacA | rlpA | HI_0029 | HI_0030 | Penicillin-binding protein 5 (dacA); Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; Belongs to the peptidase S11 family. | Lipoprotein, putative; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. | 0.766 |
dacB | dacA | HI_1330 | HI_0029 | D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase (dacB); Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction; Belongs to the peptidase S13 family. | Penicillin-binding protein 5 (dacA); Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; Belongs to the peptidase S11 family. | 0.833 |
dacB | ftsI | HI_1330 | HI_1132 | D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase (dacB); Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction; Belongs to the peptidase S13 family. | Penicillin-binding protein 3 (ftsI); Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | 0.655 |
dacB | mrcA | HI_1330 | HI_0440 | D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase (dacB); Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction; Belongs to the peptidase S13 family. | Penicillin-binding protein 1A (ponA); Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | 0.558 |
dacB | mrcB | HI_1330 | HI_1725 | D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase (dacB); Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction; Belongs to the peptidase S13 family. | Penicillin-binding protein 1B (ponB); Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits) (By similarity). | 0.554 |