Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
HI_0036ABC transporter, ATP-binding protein; Similar to SP:Q50614 PID:1483552 percent identity: 42.52; identified by sequence similarity; putative. (592 aa)    
Predicted Functional Partners:
mreB
Rod shape-determining protein (mreB); Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
       0.618
HI_1369
Conserved hypothetical protein; Similar to SP:P31827 GB:X71917 PID:311346 GB:U00096 PID:1787771 percent identity: 25.46; identified by sequence similarity; putative; To E.coli YddB.
  
  
 0.515
HI_0035
Conserved hypothetical protein; Similar to GB:L10328 SP:P29211 GB:M94104 PID:290534 PID:147371 percent identity: 63.41; identified by sequence similarity; putative.
       0.490
mreC
Rod shape-determining protein (mreC); Involved in formation and maintenance of cell shape.
       0.452
mreD
Rod shape-determining protein (mreD); Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins (By similarity); Belongs to the MreD family.
       0.452
HI_1467
ABC transporter, ATP-binding protein; Similar to SP:Q50614 PID:1483552 percent identity: 36.97; identified by sequence similarity; putative.
     
  0.441
recA
recA protein (recA); Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage. Plays a central role in DNA metabolism, participating in general homologous recombination, recombinational (postreplication) DNA repair, and prophage induction; Belongs to the RecA family.
    
   0.419
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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