STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HI_0044Conserved hypothetical transmembrane protein; Similar to SP:P06967 GB:X00547 PID:41284 GB:U00096 PID:1787205 percent identity: 61.47; identified by sequence similarity; putative. (220 aa)    
Predicted Functional Partners:
msrAB
Peptide methionine sulfoxide reductase (msrA); Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
  
   0.603
HI_0042
Conserved hypothetical protein; Similar to SP:P39219 GB:U00096 PID:1786244 percent identity: 34.95; identified by sequence similarity; putative.
       0.596
HI_0043
Conserved hypothetical transmembrane protein; Similar to SP:P45525 GB:U00096 PID:1787582 percent identity: 42.69; identified by sequence similarity; putative.
       0.596
cvpA
Colicin V production protein (cvpA); Similar to GB:J01666 SP:P08550 PID:146367 PID:147415 GB:U00096 percent identity: 64.74; identified by sequence similarity; putative.
  
    0.547
HI_0040
Conserved hypothetical protein; Similar to PID:1944176 percent identity: 47.58; identified by sequence similarity; putative.
       0.489
xthA
Exodeoxyribonuclease III (xthA); Major apurinic-apyrimidinic endonuclease of E.coli. It removes the damaged DNA at cytosines and guanines by cleaving on the 3'-side of the AP site by a beta-elimination reaction (By similarity). Belongs to the DNA repair enzymes AP/ExoA family.
       0.489
HI_0045
Conserved hypothetical protein; Similar to GB:U14003 SP:P39187 PID:471102 PID:537057 GB:U00096 percent identity: 40.66; identified by sequence similarity; putative.
 
     0.486
cysB
Cys regulon transcriptional activator (cysB); This protein is a positive regulator of gene expression for the cysteine regulon. The inducer for CysB is N-acetylserine (By similarity).
  
     0.437
rseB
sigma-E factor regulatory protein (rseB); Negatively modulates the activity of sigma-E (RpoE) by stabilizing RseA under non-stress conditions. Although not essential for association of sigma-E with Rsea it increases their affinity 2- to 3-fold. When bound to RseA it prevents proteolysis by DegS, which is probably relieved by lipopolysaccharide binding (LPS) (By similarity). Belongs to the RseB family.
  
     0.407
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.