STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fbpAiron(III) ABC transporter, periplasmic-binding protein (hitA); Part of the ABC transporter complex FbpABC (TC 3.A.1.10.1) involved in Fe(3+) ions import. This protein specifically binds Fe(3+) and is involved in its transmembrane transport (By similarity). Belongs to the bacterial solute-binding protein 1 family. (294 aa)    
Predicted Functional Partners:
fbpB2
iron(III) ABC transporter, permease protein (hitB); Part of the ABC transporter complex FbpABC (TC 3.A.1.10.1) involved in Fe(3+) ions import. Probably responsible for the translocation of the substrate across the membrane (By similarity).
 
 
 0.989
fbpC2
iron(III) ABC transporter, ATP-binding protein (hitC); Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system.
 
 
 0.961
fbpB1
Predicted coding region HI0129; Part of the ABC transporter complex FbpABC (TC 3.A.1.10.1) involved in Fe(3+) ions import. Probably responsible for the translocation of the substrate across the membrane (By similarity).
 
 
 0.788
fbpC1
Ferric ABC transporter, ATP-binding protein (afuC); Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system.
 
 
 0.684
HI_0131
afuA protein; Similar to PID:1469286 PID:1477455 percent identity: 74.57; identified by sequence similarity; putative.
  
  
 0.637
HI_0854
Conserved hypothetical protein; Involved in heme iron utilization. Catalyzes the degradation of heme to biliverdin, with the release of iron and carbon monoxide.
   
    0.562
tbpA
Transferrin-binding protein 1 precursor (tbp1); Acts as a transferrin receptor and is required for transferrin utilization; Belongs to the TonB-dependent receptor family.
  
  
 0.550
thiP
Thiamin ABC transporter, permease protein, putative; Part of the ABC transporter complex ThiBPQ involved in thiamine import. Probably responsible for the translocation of the substrate across the membrane.
  
 
 0.539
tonB
tonB protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Required for heme utilization and virulence; Belongs to the TonB family.
 
  
 0.530
hxuC
Heme-hemopexin utilization protein C; Required for utilization of free heme at low concentrations. Belongs to the TonB-dependent receptor family.
  
  
 0.499
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.