Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
HI_0125Conserved hypothetical protein; Similar to SP:P32702 PID:396399 GB:U00096 PID:1790499 percent identity: 75.90; identified by sequence similarity; putative. (438 aa)    
Predicted Functional Partners:
purL
Phosphoribosylformylglycinamidine synthase (purL); Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
  
  
 0.830
uraA
Uracil permease (uraA); Transport of uracil in the cell; Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily.
 
  
 0.534
ppa
Inorganic pyrophosphatase (ppa); Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
       0.467
purE
Phosphoribosylaminoimidazole carboxylase, catalytic subunit (purE); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
    0.448
purK
Phosphoribosylaminoimidazole carboxylase, ATPase subunit (purK); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family.
  
    0.431
apt
Adenine phosphoribosyltransferase (apt); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
 
  
 0.418
HI_0221.1
Predicted coding region HI0221.1; Brute Force ORF; identified by GeneMark; putative; Belongs to the IMPDH/GMPR family.
  
  
 0.417
guaA
GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP.
     
 0.408
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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