dcd protein (Haemophilus influenzae) - STRING interaction network

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dcd

Deoxycytidine triphosphate deaminase (dcd); Catalyzes the deamination of dCTP to dUTP. (195 aa)

Predicted Functional Partners:

dut

0.972

nrdD

0.958

ndk

0.930

HI_0134

0.832

udk

0.810

sotB

0.807

thyA

0.663

nrdA

0.659

mazG

0.608

tmk

0.551

Your Current Organism:

Haemophilus influenzae

NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HI_0134	dcd	HI_0134	HI_0133	Predicted coding region HI0134; Hypothetical protein; identified by GeneMark; putative.	Deoxycytidine triphosphate deaminase (dcd); Catalyzes the deamination of dCTP to dUTP.	0.832
HI_0134	sotB	HI_0134	HI_0135	Predicted coding region HI0134; Hypothetical protein; identified by GeneMark; putative.	Conserved hypothetical transmembrane protein; Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites; Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family.	0.805
HI_0134	udk	HI_0134	HI_0132	Predicted coding region HI0134; Hypothetical protein; identified by GeneMark; putative.	Uridine kinase (udk); Similar to SP:P31218 GB:X71492 PID:296947 GB:U00096 PID:1736770 percent identity: 67.82; identified by sequence similarity; putative.	0.829
dcd	HI_0134	HI_0133	HI_0134	Deoxycytidine triphosphate deaminase (dcd); Catalyzes the deamination of dCTP to dUTP.	Predicted coding region HI0134; Hypothetical protein; identified by GeneMark; putative.	0.832
dcd	dut	HI_0133	HI_0954	Deoxycytidine triphosphate deaminase (dcd); Catalyzes the deamination of dCTP to dUTP.	Deoxyuridinetriphosphatase (dut); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.	0.972
dcd	mazG	HI_0133	HI_0460	Deoxycytidine triphosphate deaminase (dcd); Catalyzes the deamination of dCTP to dUTP.	mazG protein (mazG); Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazE-MazF toxin- antitoxin (TA) system that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp produced by RelA under amino acid starvation, thus protecting the cell from the toxicity of MazF. Reduction of (p)ppGpp can be achieved by direct degradation of (p)ppGpp or by degradation of NTPs, which are substrates for (p)ppGpp synthesis by RelA (By similarity); Belongs to the nucleoside triphosphate pyrophos [...]	0.608
dcd	ndk	HI_0133	HI_0876	Deoxycytidine triphosphate deaminase (dcd); Catalyzes the deamination of dCTP to dUTP.	Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.930
dcd	nrdA	HI_0133	HI_1659	Deoxycytidine triphosphate deaminase (dcd); Catalyzes the deamination of dCTP to dUTP.	Ribonucleoside-diphosphate reductase, alpha chain (nrdA); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).	0.659
dcd	nrdD	HI_0133	HI_0075	Deoxycytidine triphosphate deaminase (dcd); Catalyzes the deamination of dCTP to dUTP.	Anaerobic ribonucleoside-triphosphate reductase (nrdD); Catalyzes the conversion of ribonucleotides into deoxyribonucleotides, which are required for DNA synthesis and repair. Belongs to the anaerobic ribonucleoside-triphosphate reductase family.	0.958
dcd	sotB	HI_0133	HI_0135	Deoxycytidine triphosphate deaminase (dcd); Catalyzes the deamination of dCTP to dUTP.	Conserved hypothetical transmembrane protein; Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites; Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family.	0.807
dcd	thyA	HI_0133	HI_0905	Deoxycytidine triphosphate deaminase (dcd); Catalyzes the deamination of dCTP to dUTP.	Thymidylate synthetase (thyA); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.663
dcd	tmk	HI_0133	HI_0456	Deoxycytidine triphosphate deaminase (dcd); Catalyzes the deamination of dCTP to dUTP.	Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.	0.551
dcd	udk	HI_0133	HI_0132	Deoxycytidine triphosphate deaminase (dcd); Catalyzes the deamination of dCTP to dUTP.	Uridine kinase (udk); Similar to SP:P31218 GB:X71492 PID:296947 GB:U00096 PID:1736770 percent identity: 67.82; identified by sequence similarity; putative.	0.810
dut	dcd	HI_0954	HI_0133	Deoxyuridinetriphosphatase (dut); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.	Deoxycytidine triphosphate deaminase (dcd); Catalyzes the deamination of dCTP to dUTP.	0.972
dut	mazG	HI_0954	HI_0460	Deoxyuridinetriphosphatase (dut); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.	mazG protein (mazG); Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazE-MazF toxin- antitoxin (TA) system that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp produced by RelA under amino acid starvation, thus protecting the cell from the toxicity of MazF. Reduction of (p)ppGpp can be achieved by direct degradation of (p)ppGpp or by degradation of NTPs, which are substrates for (p)ppGpp synthesis by RelA (By similarity); Belongs to the nucleoside triphosphate pyrophos [...]	0.436
dut	ndk	HI_0954	HI_0876	Deoxyuridinetriphosphatase (dut); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.	Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.965
dut	nrdA	HI_0954	HI_1659	Deoxyuridinetriphosphatase (dut); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.	Ribonucleoside-diphosphate reductase, alpha chain (nrdA); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).	0.758
dut	nrdD	HI_0954	HI_0075	Deoxyuridinetriphosphatase (dut); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.	Anaerobic ribonucleoside-triphosphate reductase (nrdD); Catalyzes the conversion of ribonucleotides into deoxyribonucleotides, which are required for DNA synthesis and repair. Belongs to the anaerobic ribonucleoside-triphosphate reductase family.	0.967
dut	thyA	HI_0954	HI_0905	Deoxyuridinetriphosphatase (dut); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.	Thymidylate synthetase (thyA); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.983
dut	tmk	HI_0954	HI_0456	Deoxyuridinetriphosphatase (dut); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.	Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.	0.950