Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ompP2Outer membrane protein P2 (ompP2); Forms pores that allow passive diffusion of small molecules across the outer membrane. (359 aa)    
Predicted Functional Partners:
ompA
Outer membrane protein P5 (ompA); With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage; Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family.
   
 0.907
mlaA
Lipoprotein (vacJ); Involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Belongs to the MlaA family.
   
 
 0.870
pal
Peptidoglycan-associated outer membrane lipoprotein (pal); Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
   
 
 0.805
ompP1
Long-chain fatty acid transport protein (fadL); Similar to GB:M60607 SP:P10384 GB:Y00552 PID:145910 PID:41372 percent identity: 42.79; identified by sequence similarity; putative.
      
 0.513
glpQ
Glycerophosphoryl diester phosphodiesterase (glpQ); Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols. Has a specific affinity for human immunoglobulin D myeloma protein.
      
 0.485
HI_0926
Predicted coding region HI0926; Hypothetical protein; identified by GeneMark; putative.
      
 0.475
fucK
Fuculokinase (fucK); Catalyzes the phosphorylation of L-fuculose. Belongs to the FGGY kinase family.
      
 0.446
degS
Protease (degS); A site-1 protease (S1P) that cleaves the peptide bond between 'Val-148' and 'Ser-149' in RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. When heat shock or other environmental stresses disrupt protein folding in the periplasm, DegS senses the accumulation of unassembled outer membrane porins (OMP) and then initiates RseA (anti sigma-E factor) degradation by cleaving its periplasmic domain, making it a substrate for subsequent cleavage by RseP. This cascade ultimately leads to the sigma-E-driven expression of a variety of factors dealing with folding [...]
    
 
 0.444
HI_1259
Periplasmic serine protease; Similar to SP:P39099 PID:558912 PID:606173 PID:984379 GB:U00096 percent identity: 59.30; identified by sequence similarity; putative.
    
 
 0.444
mlaC
Conserved hypothetical protein; Involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. May transfer phospholipid across the periplasmic space and deliver it to the MlaFEDB complex at the inner membrane. Belongs to the MlaC/ttg2D family.
    
 
 0.436
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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