Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
siaPConserved hypothetical protein; Part of the tripartite ATP-independent periplasmic (TRAP) transport system SiaPT involved in the uptake of sialic acid. This protein specifically binds sialic acid with high affinity. (329 aa)    
Predicted Functional Partners:
siaT
Conserved hypothetical transmembrane protein; Part of the tripartite ATP-independent periplasmic (TRAP) transport system SiaPT involved in the uptake of sialic acid. In the N-terminal section; belongs to the TRAP transporter small permease family.
 
 
 0.989
HI_0050
Conserved hypothetical transmembrane protein; Similar to SP:P37675 PID:466716 GB:U00096 PID:1790003 percent identity: 47.93; identified by sequence similarity; putative.
 
 0.827
HI_1030
Conserved hypothetical transmembrane protein; Similar to SP:P37674 PID:466715 GB:U00096 PID:1790002 percent identity: 37.50; identified by sequence similarity; putative.
 
  
 0.824
HI_1029
Conserved hypothetical transmembrane protein; Similar to SP:P37675 PID:466716 GB:U00096 PID:1790003 percent identity: 65.88; identified by sequence similarity; putative.
 
 0.823
HI_0051
Conserved hypothetical transmembrane protein; Similar to SP:P37674 PID:466715 GB:U00096 PID:1790002 percent identity: 28.15; identified by sequence similarity; putative.
 
  
 0.808
nanM
Conserved hypothetical protein; Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity); Belongs to the NanM family.
 
   
 0.752
nanA
N-acetylneuraminate lyase (nanA); Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate; Belongs to the DapA family. NanA subfamily.
     
 0.654
nanE
Conserved hypothetical protein; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P).
     
 0.652
nanK
Glucose kinase, putative; Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P; Belongs to the ROK (NagC/XylR) family. NanK subfamily.
     
 0.616
nagB
Glucosamine-6-phosphate isomerase (nagB); Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
     
 0.550
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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