| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HI_0044 | hflK | HI_0044 | HI_0151 | Conserved hypothetical transmembrane protein; Similar to SP:P06967 GB:X00547 PID:41284 GB:U00096 PID:1787205 percent identity: 61.47; identified by sequence similarity; putative. | hflK protein (hflK); HflC and HflK could encode or regulate a protease. | 0.527 |
| HI_0152 | hflC | HI_0152 | HI_0150 | Predicted coding region HI0152; May transfer the 4'-phosphopantetheine moiety from coenzyme A (CoA) to a serine residue of a carrier protein domain; Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family. | hflC protein (hflC); HflC and HflK could regulate a protease. | 0.520 |
| HI_0152 | hflK | HI_0152 | HI_0151 | Predicted coding region HI0152; May transfer the 4'-phosphopantetheine moiety from coenzyme A (CoA) to a serine residue of a carrier protein domain; Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family. | hflK protein (hflK); HflC and HflK could encode or regulate a protease. | 0.520 |
| HI_1259 | ftsH | HI_1259 | HI_1335 | Periplasmic serine protease; Similar to SP:P39099 PID:558912 PID:606173 PID:984379 GB:U00096 percent identity: 59.30; identified by sequence similarity; putative. | Cell division protein (ftsH); Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | 0.441 |
| HI_1259 | hflK | HI_1259 | HI_0151 | Periplasmic serine protease; Similar to SP:P39099 PID:558912 PID:606173 PID:984379 GB:U00096 percent identity: 59.30; identified by sequence similarity; putative. | hflK protein (hflK); HflC and HflK could encode or regulate a protease. | 0.668 |
| HI_1465 | hflC | HI_1465 | HI_0150 | Cell division ftsH-related protein; Similar to GB:M83138 SP:P28691 GB:U01376 PID:146028 PID:606116 percent identity: 77.66; identified by sequence similarity; putative; In the C-terminal section; belongs to the peptidase M41 family. | hflC protein (hflC); HflC and HflK could regulate a protease. | 0.831 |
| HI_1465 | hflK | HI_1465 | HI_0151 | Cell division ftsH-related protein; Similar to GB:M83138 SP:P28691 GB:U01376 PID:146028 PID:606116 percent identity: 77.66; identified by sequence similarity; putative; In the C-terminal section; belongs to the peptidase M41 family. | hflK protein (hflK); HflC and HflK could encode or regulate a protease. | 0.880 |
| ftsH | HI_1259 | HI_1335 | HI_1259 | Cell division protein (ftsH); Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | Periplasmic serine protease; Similar to SP:P39099 PID:558912 PID:606173 PID:984379 GB:U00096 percent identity: 59.30; identified by sequence similarity; putative. | 0.441 |
| ftsH | grpE | HI_1335 | HI_0071 | Cell division protein (ftsH); Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | Heat shock protein (grpE); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of AT [...] | 0.429 |
| ftsH | hflC | HI_1335 | HI_0150 | Cell division protein (ftsH); Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | hflC protein (hflC); HflC and HflK could regulate a protease. | 0.831 |
| ftsH | hflK | HI_1335 | HI_0151 | Cell division protein (ftsH); Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | hflK protein (hflK); HflC and HflK could encode or regulate a protease. | 0.880 |
| ftsH | yidC | HI_1335 | HI_1001 | Cell division protein (ftsH); Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | Inner membrane protein, 60 kDa (yidC); Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.552 |
| grpE | ftsH | HI_0071 | HI_1335 | Heat shock protein (grpE); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of AT [...] | Cell division protein (ftsH); Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | 0.429 |
| grpE | hflK | HI_0071 | HI_0151 | Heat shock protein (grpE); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of AT [...] | hflK protein (hflK); HflC and HflK could encode or regulate a protease. | 0.447 |
| grpE | yidC | HI_0071 | HI_1001 | Heat shock protein (grpE); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of AT [...] | Inner membrane protein, 60 kDa (yidC); Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.532 |
| hflC | HI_0152 | HI_0150 | HI_0152 | hflC protein (hflC); HflC and HflK could regulate a protease. | Predicted coding region HI0152; May transfer the 4'-phosphopantetheine moiety from coenzyme A (CoA) to a serine residue of a carrier protein domain; Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family. | 0.520 |
| hflC | HI_1465 | HI_0150 | HI_1465 | hflC protein (hflC); HflC and HflK could regulate a protease. | Cell division ftsH-related protein; Similar to GB:M83138 SP:P28691 GB:U01376 PID:146028 PID:606116 percent identity: 77.66; identified by sequence similarity; putative; In the C-terminal section; belongs to the peptidase M41 family. | 0.831 |
| hflC | ftsH | HI_0150 | HI_1335 | hflC protein (hflC); HflC and HflK could regulate a protease. | Cell division protein (ftsH); Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | 0.831 |
| hflC | hflK | HI_0150 | HI_0151 | hflC protein (hflC); HflC and HflK could regulate a protease. | hflK protein (hflK); HflC and HflK could encode or regulate a protease. | 0.995 |
| hflC | miaA | HI_0150 | HI_0068 | hflC protein (hflC); HflC and HflK could regulate a protease. | tRNA delta(2)-isopentenylpyrophosphate transferase (trpX); Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.608 |
