Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mepAPenicillin-insensitive murein endopeptidase (mepA); Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus. (286 aa)    
Predicted Functional Partners:
HI_0198
Conserved hypothetical transmembrane protein; Similar to SP:P14008 PID:41996 GB:U00096 PID:1788667 percent identity: 53.69; identified by sequence similarity; putative.
 
    0.941
lpxM
Lipid A biosynthesis (kdo)2-(lauroyl)-lipid IVA acyltransferase (msbB); Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A.
       0.682
aroC
Chorismate synthase (aroC); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
  
    0.643
HI_1637
Conserved hypothetical protein; Similar to GB:U00096 PID:1787581 percent identity: 50.00; identified by sequence similarity; putative; To E.coli YcjX.
  
     0.642
HI_1666
Conserved hypothetical protein; Similar to GB:U00096 SP:P75848 PID:1787157 percent identity: 49.73; identified by sequence similarity; putative.
  
     0.640
hmrM
Conserved hypothetical transmembrane protein; Multidrug efflux pump that functions as a Na(+)/drug antiporter. Confers resistance to norfloxacin, acriflavine, doxorubicin, ethidium bromide, tetraphenylphosphonium chloride, daunomycin, berberine and sodium deoxycholate. Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
      
 0.624
HI_0195.1
Conserved hypothetical transmembrane protein (aefA); Similar to GB:U00096 SP:P77338 PID:1707458 PID:1773147 PID:1786670 percent identity: 37.35; identified by sequence similarity; putative.
 
     0.620
HI_1667
Conserved hypothetical protein; Similar to SP:P22525 GB:X57550 PID:42044 GB:U00096 PID:1787155 percent identity: 42.12; identified by sequence similarity; putative; Belongs to the YkuD family.
  
     0.618
HI_0043
Conserved hypothetical transmembrane protein; Similar to SP:P45525 GB:U00096 PID:1787582 percent identity: 42.69; identified by sequence similarity; putative.
  
     0.575
menE
O-succinylbenzoate--CoA ligase (menE); Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA); Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily.
       0.567
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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