STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
selDSelenide, water dikinase (selD); Synthesizes selenophosphate from selenide and ATP. (323 aa)    
Predicted Functional Partners:
selA
L-seryl-tRNA selenium transferase (selA); Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
 
  
 0.979
iscS
nifS protein (nifS); Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
   
 0.948
selB
Selenocysteine-specific elongation factor (selB); Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. SelB subfamily.
 
   
 0.892
trxB
Thioredoxin reductase (trxB); Similar to GB:J03762 SP:P09625 PID:148073 PID:347239 GB:U00096 percent identity: 75.95; identified by sequence similarity; putative.
     
 0.603
ddc
L-2,4-diaminobutyrate decarboxylase; Similar to PID:893355 percent identity: 75.54; identified by sequence similarity; putative.
     
 0.581
fdhE
fdhE protein (fdhE); Necessary for formate dehydrogenase activity; Belongs to the FdhE family.
 
   
 0.567
fdhD
fdhD protein (fdhD); Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family.
     
 0.555
lpxM
Lipid A biosynthesis (kdo)2-(lauroyl)-lipid IVA acyltransferase (msbB); Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A.
       0.496
HI_0198
Conserved hypothetical transmembrane protein; Similar to SP:P14008 PID:41996 GB:U00096 PID:1788667 percent identity: 53.69; identified by sequence similarity; putative.
       0.420
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
Server load: medium (60%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.