Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
guaBInosine-5'-monophosphate dehydrogenase (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa)    
Predicted Functional Partners:
guaA
GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP.
 
 0.999
HI_0221.1
Predicted coding region HI0221.1; Brute Force ORF; identified by GeneMark; putative; Belongs to the IMPDH/GMPR family.
 
 
0.985
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase (purH); Similar to SP:P15639 GB:J05126 GB:X51950 PID:147420 PID:396345 percent identity: 77.19; identified by sequence similarity; putative.
  
 0.972
purA
Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 
 0.933
purL
Phosphoribosylformylglycinamidine synthase (purL); Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
  
  
 0.898
surE
Stationary-phase survival protein (surE); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.891
rplF
Ribosomal protein L6 (rpL6); This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.
   
   0.888
rpsB
Ribosomal protein S2 (rpS2); Similar to GB:D26562 SP:P02351 GB:V00343 PID:42842 PID:473824 percent identity: 82.16; identified by sequence similarity; putative; Belongs to the universal ribosomal protein uS2 family.
   
 
 0.877
rpsC
Ribosomal protein S3 (rpS3); Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family.
   
 
 0.869
hpt
Hypoxanthine phosphoribosyltransferase (hpt); Acts preferentially on hypoxanthine; has very low activity towards guanine. Inactive towards xanthine (By similarity). Belongs to the purine/pyrimidine phosphoribosyltransferase family.
    
 0.869
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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