Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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tonBtonB protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Required for heme utilization and virulence; Belongs to the TonB family. (270 aa)    
Predicted Functional Partners:
exbD
Biopolymer transport protein (exbD); Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
 
 
 0.997
exbB
Biopolymer transport protein (exbB); Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB (By similarity).
 
 
 0.995
HI_1369
Conserved hypothetical protein; Similar to SP:P31827 GB:X71917 PID:311346 GB:U00096 PID:1787771 percent identity: 25.46; identified by sequence similarity; putative; To E.coli YddB.
 
 0.951
tolR
Colicin transport protein (tolR); Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
 
 
 0.941
tolQ
Colicin transport protein (tolQ); Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
 
 
 0.911
hxuC
Heme-hemopexin utilization protein C; Required for utilization of free heme at low concentrations. Belongs to the TonB-dependent receptor family.
 
 
 0.823
fruA
PTS system, fructose-specific IIBC component (fruA); The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport.
     
 0.822
tolB
Colicin tolerance protein (tolB); Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
  
 
 0.803
infB
Translation initiation factor 2 (infB); One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
    
 0.778
tdhA
Hemin receptor (hemR); Heme receptor; Belongs to the TonB-dependent receptor family.
 
 
 0.759
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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