Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
HI_0258Glycosyl transferase, putative; Similar to PID:1857120 percent identity: 38.06; identified by sequence similarity; putative; Belongs to the glycosyltransferase 8 family. (330 aa)    
Predicted Functional Partners:
opsX
Lipopolysaccharide biosynthesis protein, putative; Catalyzes heptose transfer to the lipopolysaccharide core. It transfers the first L-glycero-D-manno-heptose to the phosphorylated 3- deoxy-alpha-D-manno-octulosonic acid (Kdo-P) of the inner core. Belongs to the glycosyltransferase 9 family.
  
 
 0.658
kdkA
Predicted coding region HI0260.1; Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D- manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position. To a lesser extent, can use GTP instead of ATP as substrate.
    
  0.625
HI_0260
Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
       0.563
HI_1698
Lipopolysaccharide biosynthesis protein; Similar to PID:633695 percent identity: 38.48; identified by sequence similarity; putative.
 
 
 0.549
rfaF
ADP-heptose--LPS heptosyltransferase II (rfaF); Similar to SP:P37692 PID:466758 GB:U00096 PID:1790050 percent identity: 63.58; identified by sequence similarity; putative.
  
 
 0.463
waaA
3-deoxy-d-manno-octulosonic-acid transferase (kdtA); Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of a single 3-deoxy-D-manno-octulosonate (Kdo) residue from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'- bisphosphate precursor of lipid A. Is strictly monofunctional, i.e. is capable of adding only a single Kdo residue to the acceptor lipid. Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 30 subfamily.
    
  0.435
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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