Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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hxuCHeme-hemopexin utilization protein C; Required for utilization of free heme at low concentrations. Belongs to the TonB-dependent receptor family. (723 aa)    
Predicted Functional Partners:
hxuB
Heme-hemopexin utilization protein B (hxuB); Likely functions in the release of soluble HxuA from the cell; Belongs to the TPS (TC 1.B.20) family.
     
 0.825
tonB
tonB protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Required for heme utilization and virulence; Belongs to the TonB family.
 
 
 0.823
hxuA
Heme-hemopexin utilization protein A (hxuA); Binds heme/hemopexin complexes.
     
 0.819
hup
DNA-binding protein HU-alpha (hupA); Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family.
      
 0.498
fbpA
iron(III) ABC transporter, periplasmic-binding protein (hitA); Part of the ABC transporter complex FbpABC (TC 3.A.1.10.1) involved in Fe(3+) ions import. This protein specifically binds Fe(3+) and is involved in its transmembrane transport (By similarity). Belongs to the bacterial solute-binding protein 1 family.
  
  
 0.476
HI_1706
High-affinity choline transport protein (betT); Similar to SP:P17447 GB:X52905 PID:48716 GB:U00096 PID:1657512 percent identity: 34.72; identified by sequence similarity; putative.
  
   
 0.459
tdhA
Hemin receptor (hemR); Heme receptor; Belongs to the TonB-dependent receptor family.
  
   
0.450
hbpA
Heme-binding lipoprotein (dppA); Important role in heme acquisition or metabolism; Belongs to the bacterial solute-binding protein 5 family.
      
 0.425
exbD
Biopolymer transport protein (exbD); Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
   
  
 0.410
kdkA
Predicted coding region HI0260.1; Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D- manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position. To a lesser extent, can use GTP instead of ATP as substrate.
     
 0.406
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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