Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hxuAHeme-hemopexin utilization protein A (hxuA); Binds heme/hemopexin complexes. (905 aa)    
Predicted Functional Partners:
hxuB
Heme-hemopexin utilization protein B (hxuB); Likely functions in the release of soluble HxuA from the cell; Belongs to the TPS (TC 1.B.20) family.
 
 0.990
hxuC
Heme-hemopexin utilization protein C; Required for utilization of free heme at low concentrations. Belongs to the TonB-dependent receptor family.
     
 0.819
nadR
Transcriptional regulator (nadR); This enzyme has two activities: nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity catalyzes the transfer of the AMP moiety of ATP to nicotinamide ribonucleotide to form NAD(+); In the C-terminal section; belongs to the bacterial RNK family.
   
 
  0.499
hup
DNA-binding protein HU-alpha (hupA); Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family.
   
  
 0.454
hbpA
Heme-binding lipoprotein (dppA); Important role in heme acquisition or metabolism; Belongs to the bacterial solute-binding protein 5 family.
      
 0.441
HI_1500
Predicted coding region HI1500; Hypothetical protein; identified by GeneMark; putative; To phage Mu protein gp28.
   
    0.435
tbpB
Transferrin-binding protein 2 precursor (tbp2); Acts as a transferrin receptor and is required for transferrin utilization.
      
 0.425
fldA
Flavodoxin (fldA); Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family.
  
     0.401
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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