node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HI_1464 | folB | HI_1464 | HI_0265 | Dihydropteroate synthase (folP-2); Similar to GB:L06494 SP:P26282 GB:U01376 GB:X68776 GB:X68777 percent identity: 54.15; identified by sequence similarity; putative. | Dihydroneopterin aldolase, putative; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6- hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin. | 0.862 |
HI_1464 | folC | HI_1464 | HI_1261 | Dihydropteroate synthase (folP-2); Similar to GB:L06494 SP:P26282 GB:U01376 GB:X68776 GB:X68777 percent identity: 54.15; identified by sequence similarity; putative. | Folylpolyglutamate synthase/dihydrofolate synthase (folC); Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | 0.942 |
HI_1464 | folE | HI_1464 | HI_1447 | Dihydropteroate synthase (folP-2); Similar to GB:L06494 SP:P26282 GB:U01376 GB:X68776 GB:X68777 percent identity: 54.15; identified by sequence similarity; putative. | GTP cyclohydrolase I (folE); Similar to GB:U00007 SP:P27511 GB:X63910 PID:312964 PID:405902 percent identity: 63.93; identified by sequence similarity; putative. | 0.874 |
HI_1464 | folK | HI_1464 | HI_0064 | Dihydropteroate synthase (folP-2); Similar to GB:L06494 SP:P26282 GB:U01376 GB:X68776 GB:X68777 percent identity: 54.15; identified by sequence similarity; putative. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine-pyrophosphokinase (folK); Similar to GB:D26562 SP:P26281 GB:L06495 PID:146013 PID:473801 percent identity: 56.33; identified by sequence similarity; putative. | 0.994 |
HI_1464 | ribD | HI_1464 | HI_0944 | Dihydropteroate synthase (folP-2); Similar to GB:L06494 SP:P26282 GB:U01376 GB:X68776 GB:X68777 percent identity: 54.15; identified by sequence similarity; putative. | Riboflavin biosynthesis protein (ribD); Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family. | 0.441 |
coaE | folB | HI_0890 | HI_0265 | Conserved hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Dihydroneopterin aldolase, putative; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6- hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin. | 0.554 |
coaE | folC | HI_0890 | HI_1261 | Conserved hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Folylpolyglutamate synthase/dihydrofolate synthase (folC); Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | 0.632 |
coaE | folE | HI_0890 | HI_1447 | Conserved hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | GTP cyclohydrolase I (folE); Similar to GB:U00007 SP:P27511 GB:X63910 PID:312964 PID:405902 percent identity: 63.93; identified by sequence similarity; putative. | 0.624 |
coaE | ribD | HI_0890 | HI_0944 | Conserved hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Riboflavin biosynthesis protein (ribD); Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family. | 0.570 |
folB | HI_1464 | HI_0265 | HI_1464 | Dihydroneopterin aldolase, putative; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6- hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin. | Dihydropteroate synthase (folP-2); Similar to GB:L06494 SP:P26282 GB:U01376 GB:X68776 GB:X68777 percent identity: 54.15; identified by sequence similarity; putative. | 0.862 |
folB | coaE | HI_0265 | HI_0890 | Dihydroneopterin aldolase, putative; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6- hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin. | Conserved hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.554 |
folB | folC | HI_0265 | HI_1261 | Dihydroneopterin aldolase, putative; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6- hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin. | Folylpolyglutamate synthase/dihydrofolate synthase (folC); Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | 0.851 |
folB | folE | HI_0265 | HI_1447 | Dihydroneopterin aldolase, putative; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6- hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin. | GTP cyclohydrolase I (folE); Similar to GB:U00007 SP:P27511 GB:X63910 PID:312964 PID:405902 percent identity: 63.93; identified by sequence similarity; putative. | 0.974 |
folB | folK | HI_0265 | HI_0064 | Dihydroneopterin aldolase, putative; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6- hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine-pyrophosphokinase (folK); Similar to GB:D26562 SP:P26281 GB:L06495 PID:146013 PID:473801 percent identity: 56.33; identified by sequence similarity; putative. | 0.990 |
folB | folP-A | HI_0265 | HI_1336 | Dihydroneopterin aldolase, putative; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6- hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin. | Dihydropteroate synthase (folP-1); Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.862 |
folB | murB | HI_0265 | HI_0268 | Dihydroneopterin aldolase, putative; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6- hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin. | UDP-N-acetylenolpyruvoylglucosamine reductase (murB); Cell wall formation. | 0.541 |
folB | plsY | HI_0265 | HI_0266 | Dihydroneopterin aldolase, putative; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6- hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin. | Conserved hypothetical protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. | 0.599 |
folB | queD | HI_0265 | HI_1190 | Dihydroneopterin aldolase, putative; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6- hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin. | 6-pyruvoyl tetrahydrobiopterin synthase, putative; Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. | 0.636 |
folB | ribD | HI_0265 | HI_0944 | Dihydroneopterin aldolase, putative; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6- hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin. | Riboflavin biosynthesis protein (ribD); Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family. | 0.593 |
folC | HI_1464 | HI_1261 | HI_1464 | Folylpolyglutamate synthase/dihydrofolate synthase (folC); Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | Dihydropteroate synthase (folP-2); Similar to GB:L06494 SP:P26282 GB:U01376 GB:X68776 GB:X68777 percent identity: 54.15; identified by sequence similarity; putative. | 0.942 |