node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dgkA | relA | HI_0335 | HI_0334 | Diacylglycerol kinase (dgkA); Recycling of diacylglycerol produced during the turnover of membrane phospholipid. | GTP pyrophosphokinase (relA); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). | 0.756 |
ndk | relA | HI_0876 | HI_0334 | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | GTP pyrophosphokinase (relA); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). | 0.782 |
ndk | rplF | HI_0876 | HI_0793 | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Ribosomal protein L6 (rpL6); This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. | 0.646 |
ndk | rplS | HI_0876 | HI_0201 | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Ribosomal protein L19 (rpL19); This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.703 |
ndk | rpmA | HI_0876 | HI_0879 | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Ribosomal protein L27 (rpL27); Similar to GB:D13267 SP:P02427 PID:216637 PID:606123 GB:U00096 percent identity: 87.06; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL27 family. | 0.845 |
ndk | rpsF | HI_0876 | HI_0547 | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Ribosomal protein S6 (rpS6); Binds together with S18 to 16S ribosomal RNA; Belongs to the bacterial ribosomal protein bS6 family. | 0.999 |
ndk | rpsM | HI_0876 | HI_0799 | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Ribosomal protein S13 (rpS13); Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. | 0.659 |
ndk | spoT | HI_0876 | HI_1741 | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Guanosine-3',5'-bis(diphosphate) 3'- pyrophosphohydrolase (spoT); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp (By similarity); Belongs to the RelA/SpoT family. | 0.782 |
ppx | relA | HI_0695 | HI_0334 | Exopolyphosphatase, putative; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. | GTP pyrophosphokinase (relA); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). | 0.749 |
ppx | spoT | HI_0695 | HI_1741 | Exopolyphosphatase, putative; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. | Guanosine-3',5'-bis(diphosphate) 3'- pyrophosphohydrolase (spoT); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp (By similarity); Belongs to the RelA/SpoT family. | 0.596 |
relA | dgkA | HI_0334 | HI_0335 | GTP pyrophosphokinase (relA); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). | Diacylglycerol kinase (dgkA); Recycling of diacylglycerol produced during the turnover of membrane phospholipid. | 0.756 |
relA | ndk | HI_0334 | HI_0876 | GTP pyrophosphokinase (relA); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.782 |
relA | ppx | HI_0334 | HI_0695 | GTP pyrophosphokinase (relA); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). | Exopolyphosphatase, putative; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. | 0.749 |
relA | rplF | HI_0334 | HI_0793 | GTP pyrophosphokinase (relA); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). | Ribosomal protein L6 (rpL6); This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. | 0.750 |
relA | rplJ | HI_0334 | HI_0640 | GTP pyrophosphokinase (relA); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). | Ribosomal protein L10 (rpL10); Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. | 0.791 |
relA | rplS | HI_0334 | HI_0201 | GTP pyrophosphokinase (relA); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). | Ribosomal protein L19 (rpL19); This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.729 |
relA | rpmA | HI_0334 | HI_0879 | GTP pyrophosphokinase (relA); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). | Ribosomal protein L27 (rpL27); Similar to GB:D13267 SP:P02427 PID:216637 PID:606123 GB:U00096 percent identity: 87.06; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL27 family. | 0.733 |
relA | rpsF | HI_0334 | HI_0547 | GTP pyrophosphokinase (relA); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). | Ribosomal protein S6 (rpS6); Binds together with S18 to 16S ribosomal RNA; Belongs to the bacterial ribosomal protein bS6 family. | 0.785 |
relA | rpsM | HI_0334 | HI_0799 | GTP pyrophosphokinase (relA); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). | Ribosomal protein S13 (rpS13); Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. | 0.745 |
relA | spoT | HI_0334 | HI_1741 | GTP pyrophosphokinase (relA); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). | Guanosine-3',5'-bis(diphosphate) 3'- pyrophosphohydrolase (spoT); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp (By similarity); Belongs to the RelA/SpoT family. | 0.812 |