Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
HI_0367Conserved hypothetical protein; Similar to SP:P27434 GB:D21149 GB:U02965 GB:X64451 PID:41541 percent identity: 26.33; identified by sequence similarity; putative. (303 aa)    
Predicted Functional Partners:
ispG
gcpE protein (gcpE); Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.
  
    0.879
mreB
Rod shape-determining protein (mreB); Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
   
 
 0.872
HI_0370
Conserved hypothetical protein; Similar to GB:U00096 PID:1788860 percent identity: 36.50; identified by sequence similarity; putative.
 
    0.868
hisS
histidyl-tRNA synthetase (hisS); Similar to GB:M11843 SP:P04804 PID:146372 GB:U00096 PID:1788861 percent identity: 66.82; identified by sequence similarity; putative.
  
    0.811
pgsA
Phosphatidylglycerophosphate synthase (pgsA); This protein catalyzes the committed step to the synthesis of the acidic phospholipids; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
  
    0.754
HI_0366
Fimbrial biogenesis and twitching motility protein, putative; Similar to PID:1162960 percent identity: 33.59; identified by sequence similarity; putative.
  
    0.636
mreD
Rod shape-determining protein (mreD); Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins (By similarity); Belongs to the MreD family.
 
  
 0.629
mreC
Rod shape-determining protein (mreC); Involved in formation and maintenance of cell shape.
 
 
 
 0.520
rlmN
Conserved hypothetical protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family.
  
    0.518
mrdA
Penicillin-binding protein 2 (pbp2); Catalyzes cross-linking of the peptidoglycan cell wall.
  
 
 0.516
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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