node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HI_0379 | fdx | HI_0379 | HI_0372 | Conserved hypothetical protein; Similar to GB:U00096 PID:1788880 percent identity: 63.38; identified by sequence similarity; putative. | Ferredoxin (fdx-1); Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; Belongs to the adrenodoxin/putidaredoxin family. | 0.607 |
HI_0379 | hscB | HI_0379 | HI_0375 | Conserved hypothetical protein; Similar to GB:U00096 PID:1788880 percent identity: 63.38; identified by sequence similarity; putative. | Conserved hypothetical protein; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity); Belongs to the HscB family. | 0.867 |
HI_0379 | iscA | HI_0379 | HI_0376 | Conserved hypothetical protein; Similar to GB:U00096 PID:1788880 percent identity: 63.38; identified by sequence similarity; putative. | Conserved hypothetical protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system (By similarity); Belongs to the HesB/IscA family. | 0.751 |
HI_0379 | iscS | HI_0379 | HI_0378 | Conserved hypothetical protein; Similar to GB:U00096 PID:1788880 percent identity: 63.38; identified by sequence similarity; putative. | nifS protein (nifS); Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.967 |
HI_0379 | iscU | HI_0379 | HI_0377 | Conserved hypothetical protein; Similar to GB:U00096 PID:1788880 percent identity: 63.38; identified by sequence similarity; putative. | iscU protein (iscU); A scaffold on which IscS assembles Fe-S clusters. Subsequently gives the nascent cluster to other proteins. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters (By similarity). | 0.891 |
HI_0379 | nfuA | HI_0379 | HI_0433 | Conserved hypothetical protein; Similar to GB:U00096 PID:1788880 percent identity: 63.38; identified by sequence similarity; putative. | orfG protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.594 |
HI_1343 | iscU | HI_1343 | HI_0377 | Predicted coding region HI1343; Hypothetical protein; identified by GeneMark; putative; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily. | iscU protein (iscU); A scaffold on which IscS assembles Fe-S clusters. Subsequently gives the nascent cluster to other proteins. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters (By similarity). | 0.913 |
HI_1343 | nfuA | HI_1343 | HI_0433 | Predicted coding region HI1343; Hypothetical protein; identified by GeneMark; putative; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily. | orfG protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.407 |
csd | iscU | HI_1295 | HI_0377 | nifS protein, putative; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. | iscU protein (iscU); A scaffold on which IscS assembles Fe-S clusters. Subsequently gives the nascent cluster to other proteins. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters (By similarity). | 0.913 |
csd | nfuA | HI_1295 | HI_0433 | nifS protein, putative; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. | orfG protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.407 |
cyaY | fdx | HI_0727.1 | HI_0372 | cyaY protein (cyaY); Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Ferredoxin (fdx-1); Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; Belongs to the adrenodoxin/putidaredoxin family. | 0.915 |
cyaY | hscA | HI_0727.1 | HI_0373 | cyaY protein (cyaY); Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Heat shock protein (hscA); Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB (By similarity). | 0.642 |
cyaY | hscB | HI_0727.1 | HI_0375 | cyaY protein (cyaY); Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Conserved hypothetical protein; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity); Belongs to the HscB family. | 0.854 |
cyaY | iscS | HI_0727.1 | HI_0378 | cyaY protein (cyaY); Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | nifS protein (nifS); Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.999 |
cyaY | iscU | HI_0727.1 | HI_0377 | cyaY protein (cyaY); Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | iscU protein (iscU); A scaffold on which IscS assembles Fe-S clusters. Subsequently gives the nascent cluster to other proteins. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters (By similarity). | 0.999 |
cyaY | nfuA | HI_0727.1 | HI_0433 | cyaY protein (cyaY); Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | orfG protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.627 |
fdx | HI_0379 | HI_0372 | HI_0379 | Ferredoxin (fdx-1); Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; Belongs to the adrenodoxin/putidaredoxin family. | Conserved hypothetical protein; Similar to GB:U00096 PID:1788880 percent identity: 63.38; identified by sequence similarity; putative. | 0.607 |
fdx | cyaY | HI_0372 | HI_0727.1 | Ferredoxin (fdx-1); Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; Belongs to the adrenodoxin/putidaredoxin family. | cyaY protein (cyaY); Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | 0.915 |
fdx | hscA | HI_0372 | HI_0373 | Ferredoxin (fdx-1); Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; Belongs to the adrenodoxin/putidaredoxin family. | Heat shock protein (hscA); Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB (By similarity). | 0.966 |
fdx | hscB | HI_0372 | HI_0375 | Ferredoxin (fdx-1); Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; Belongs to the adrenodoxin/putidaredoxin family. | Conserved hypothetical protein; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity); Belongs to the HscB family. | 0.987 |