Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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Score
tolRColicin transport protein (tolR); Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (139 aa)    
Predicted Functional Partners:
tolQ
Colicin transport protein (tolQ); Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
 
 
 0.997
tolB
Colicin tolerance protein (tolB); Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
  
 0.992
pal
Peptidoglycan-associated outer membrane lipoprotein (pal); Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
 
 
 
 0.951
tonB
tonB protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Required for heme utilization and virulence; Belongs to the TonB family.
 
 
 0.941
exbB
Biopolymer transport protein (exbB); Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB (By similarity).
 
 
 0.935
tolA
Outer membrane integrity protein (tolA); Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
  
   0.858
ybgC
Conserved hypothetical protein; Displays acyl-CoA thioesterase activity with short chain aliphatic acyl-CoA thioesters, such as propionyl-CoA and butyryl-CoA. Enzyme activity is relatively low, suggesting that the acyl-CoA thioesters used in the assays are not the physiological substrates. Has no detectable activity with 4-hydroxybenzoyl-CoA, lauroyl-CoA (C12:0), arachidoyl-CoA (C20:0) and arachidonoyl-CoA (C20:4).
  
  
 0.837
exbD
Biopolymer transport protein (exbD); Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
  
   
 0.708
bamD
Lipoprotein, putative; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
 
    0.701
ompA
Outer membrane protein P5 (ompA); With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage; Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family.
 
 
 
 0.688
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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