node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HI_0358 | licA | HI_0358 | HI_1537 | Transcriptional activator, putative; Similar to GB:AE000511 PID:2314455 percent identity: 34.29; identified by sequence similarity; putative; Belongs to the thiaminase-2 family. | Lic-1 operon protein (licA); Mediates phase variation of the LPS epitopes. Phase variation of H.influenza LPS epitopes expressed by LicA is determined by a translational switch (By similarity). | 0.596 |
HI_0358 | moeB | HI_0358 | HI_1449 | Transcriptional activator, putative; Similar to GB:AE000511 PID:2314455 percent identity: 34.29; identified by sequence similarity; putative; Belongs to the thiaminase-2 family. | Molybdopterin biosynthesis protein (moeB); Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein MoaD; Belongs to the HesA/MoeB/ThiF family. | 0.428 |
HI_0358 | thiD | HI_0358 | HI_0416 | Transcriptional activator, putative; Similar to GB:AE000511 PID:2314455 percent identity: 34.29; identified by sequence similarity; putative; Belongs to the thiaminase-2 family. | Phosphomethylpyrimidine kinase (thiD); Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. | 0.997 |
HI_0358 | thiE | HI_0358 | HI_0417 | Transcriptional activator, putative; Similar to GB:AE000511 PID:2314455 percent identity: 34.29; identified by sequence similarity; putative; Belongs to the thiaminase-2 family. | Thiamin-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.971 |
HI_0358 | thiL | HI_0358 | HI_1305 | Transcriptional activator, putative; Similar to GB:AE000511 PID:2314455 percent identity: 34.29; identified by sequence similarity; putative; Belongs to the thiaminase-2 family. | Thiamin-monophosphate kinase (thiL); Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.606 |
HI_0358 | thiM | HI_0358 | HI_0415 | Transcriptional activator, putative; Similar to GB:AE000511 PID:2314455 percent identity: 34.29; identified by sequence similarity; putative; Belongs to the thiaminase-2 family. | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. | 0.849 |
HI_0418 | HI_0419 | HI_0418 | HI_0419 | Transport protein, putative; Similar to GB:L42023 SP:P44610 PID:1003458 PID:1222206 PID:1204537 percent identity: 60.92; identified by sequence similarity; putative. | Protease, putative; Similar to GB:U00096 SP:P76403 PID:1736789 PID:1736801 PID:1788397 percent identity: 79.52; identified by sequence similarity; putative; Belongs to the peptidase U32 family. | 0.462 |
HI_0418 | thiD | HI_0418 | HI_0416 | Transport protein, putative; Similar to GB:L42023 SP:P44610 PID:1003458 PID:1222206 PID:1204537 percent identity: 60.92; identified by sequence similarity; putative. | Phosphomethylpyrimidine kinase (thiD); Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. | 0.757 |
HI_0418 | thiE | HI_0418 | HI_0417 | Transport protein, putative; Similar to GB:L42023 SP:P44610 PID:1003458 PID:1222206 PID:1204537 percent identity: 60.92; identified by sequence similarity; putative. | Thiamin-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.773 |
HI_0418 | thiM | HI_0418 | HI_0415 | Transport protein, putative; Similar to GB:L42023 SP:P44610 PID:1003458 PID:1222206 PID:1204537 percent identity: 60.92; identified by sequence similarity; putative. | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. | 0.757 |
HI_0419 | HI_0418 | HI_0419 | HI_0418 | Protease, putative; Similar to GB:U00096 SP:P76403 PID:1736789 PID:1736801 PID:1788397 percent identity: 79.52; identified by sequence similarity; putative; Belongs to the peptidase U32 family. | Transport protein, putative; Similar to GB:L42023 SP:P44610 PID:1003458 PID:1222206 PID:1204537 percent identity: 60.92; identified by sequence similarity; putative. | 0.462 |
HI_0419 | thiD | HI_0419 | HI_0416 | Protease, putative; Similar to GB:U00096 SP:P76403 PID:1736789 PID:1736801 PID:1788397 percent identity: 79.52; identified by sequence similarity; putative; Belongs to the peptidase U32 family. | Phosphomethylpyrimidine kinase (thiD); Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. | 0.464 |
HI_0419 | thiE | HI_0419 | HI_0417 | Protease, putative; Similar to GB:U00096 SP:P76403 PID:1736789 PID:1736801 PID:1788397 percent identity: 79.52; identified by sequence similarity; putative; Belongs to the peptidase U32 family. | Thiamin-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.465 |
HI_0419 | thiM | HI_0419 | HI_0415 | Protease, putative; Similar to GB:U00096 SP:P76403 PID:1736789 PID:1736801 PID:1788397 percent identity: 79.52; identified by sequence similarity; putative; Belongs to the peptidase U32 family. | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. | 0.454 |
licA | HI_0358 | HI_1537 | HI_0358 | Lic-1 operon protein (licA); Mediates phase variation of the LPS epitopes. Phase variation of H.influenza LPS epitopes expressed by LicA is determined by a translational switch (By similarity). | Transcriptional activator, putative; Similar to GB:AE000511 PID:2314455 percent identity: 34.29; identified by sequence similarity; putative; Belongs to the thiaminase-2 family. | 0.596 |
licA | thiD | HI_1537 | HI_0416 | Lic-1 operon protein (licA); Mediates phase variation of the LPS epitopes. Phase variation of H.influenza LPS epitopes expressed by LicA is determined by a translational switch (By similarity). | Phosphomethylpyrimidine kinase (thiD); Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. | 0.581 |
licA | thiE | HI_1537 | HI_0417 | Lic-1 operon protein (licA); Mediates phase variation of the LPS epitopes. Phase variation of H.influenza LPS epitopes expressed by LicA is determined by a translational switch (By similarity). | Thiamin-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.569 |
licA | thiL | HI_1537 | HI_1305 | Lic-1 operon protein (licA); Mediates phase variation of the LPS epitopes. Phase variation of H.influenza LPS epitopes expressed by LicA is determined by a translational switch (By similarity). | Thiamin-monophosphate kinase (thiL); Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.621 |
moeB | HI_0358 | HI_1449 | HI_0358 | Molybdopterin biosynthesis protein (moeB); Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein MoaD; Belongs to the HesA/MoeB/ThiF family. | Transcriptional activator, putative; Similar to GB:AE000511 PID:2314455 percent identity: 34.29; identified by sequence similarity; putative; Belongs to the thiaminase-2 family. | 0.428 |
moeB | thiD | HI_1449 | HI_0416 | Molybdopterin biosynthesis protein (moeB); Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein MoaD; Belongs to the HesA/MoeB/ThiF family. | Phosphomethylpyrimidine kinase (thiD); Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. | 0.703 |