Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
HI_0418Transport protein, putative; Similar to GB:L42023 SP:P44610 PID:1003458 PID:1222206 PID:1204537 percent identity: 60.92; identified by sequence similarity; putative. (447 aa)    
Predicted Functional Partners:
thiE
Thiamin-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
       0.773
thiM
Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
       0.757
thiD
Phosphomethylpyrimidine kinase (thiD); Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.
       0.757
menF
Menaquinone-specific isochorismate synthase (menF); Catalyzes the conversion of chorismate to isochorismate.
   
  
 0.590
menD
2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase/2-oxoglutarate decarboxylase (menD); Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
      
 0.588
HI_0419
Protease, putative; Similar to GB:U00096 SP:P76403 PID:1736789 PID:1736801 PID:1788397 percent identity: 79.52; identified by sequence similarity; putative; Belongs to the peptidase U32 family.
       0.462
glpC
Anaerobic glycerol-3-phosphate dehydrogenase, subunit C (glpC); Electron transfer protein; may also function as the membrane anchor for the GlpAB dimer.
      
 0.425
HI_1017
Glycerol uptake facilitator protein (glpF); Similar to GB:M99611 SP:P18156 PID:142991 PID:142997 PID:2226136 percent identity: 41.28; identified by sequence similarity; putative; Belongs to the MIP/aquaporin (TC 1.A.8) family.
      
 0.425
pheA
Chorismate mutase / prephenate dehydratase (pheA); Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
   
 
  0.406
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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