Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
dsbBDisulfide bond formation protein B (dsbB); Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein; Belongs to the DsbB family. (177 aa)    
Predicted Functional Partners:
dsbA
Periplasmic oxidoreductase (por); Involved in disulfide-bond formation. Required for HI transformation. Acts by transferring its disulfide bond to other proteins; Belongs to the thioredoxin family. DsbA subfamily.
 
 
 0.971
dsbC
Thiol:disulfide interchange protein (dsbC); Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase (By similarity).
 
 
 0.884
HI_1215
Thiol:disulfide interchange protein (dsbA); Similar to PID:840949 SP:P50024 percent identity: 22.28; identified by sequence similarity; putative.
  
 
 0.870
nhaB
Na+/H+ antiporter (nhaB); Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
  
  
 0.857
fadR
Fatty acid metabolism regulator protein (fadR); Multifunctional regulator of fatty acid metabolism.
 
   
 0.797
dsbD
Thiol:disulfide interchange protein (dsbD); Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity); Belongs to the thioredoxin family. DsbD subfamily.
   
  
 0.789
rraB
Conserved hypothetical protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
  
     0.670
slyX
slyX protein (slyX); Similar to GB:L13261 SP:P30857 PID:290468 PID:606282 GB:U00096 percent identity: 50.75; identified by sequence similarity; putative; Belongs to the SlyX family.
  
   
 0.666
metJ
Met repressor (metJ); This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family.
  
     0.624
nlpI
Conserved hypothetical protein; May be involved in cell division.
  
     0.604
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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