Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
comFCompetence protein F (comF); Involved in transformation (competence for DNA uptake). (229 aa)    
Predicted Functional Partners:
dprA
DNA processing chain A (dprA); Essential for efficient chromosomal DNA transformation but not required for plasmid transformation. Its disruption can be partially complemented by the smf gene of E.coli ; Belongs to the DprA/Smf family.
 
 
 0.950
comM
Competence protein (comM); Induced during competence development. Not needed for DNA uptake. May be involved in a recombination step.
 
  
 0.925
rec2
Recombination protein (rec2); Might contribute to transformation as a member of a membrane- bound pore complex at the base of the transformasome. It could directly interact with transforming DNA during translocation indirectly by participating in the assembly of the pore.
 
  
 0.876
comE
Competence protein E (comE); Involved in transformation (competence for DNA uptake); Belongs to the bacterial secretin family. PilQ subfamily.
     
 0.875
comB
Competence protein B (comB); Involved in transformation (competence for DNA uptake).
     
 0.852
comD
Competence protein D (comD); Involved in transformation (competence for DNA uptake).
     
 0.813
comA
Competence protein A (comA); Involved in transformation (competence for DNA uptake).
     
 0.794
comC
Competence protein C (comC); Involved in transformation (competence for DNA uptake).
       0.773
nfuA
orfG protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.
       0.656
recA
recA protein (recA); Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage. Plays a central role in DNA metabolism, participating in general homologous recombination, recombinational (postreplication) DNA repair, and prophage induction; Belongs to the RecA family.
  
  
 0.635
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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