Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
comDCompetence protein D (comD); Involved in transformation (competence for DNA uptake). (137 aa)    
Predicted Functional Partners:
comE
Competence protein E (comE); Involved in transformation (competence for DNA uptake); Belongs to the bacterial secretin family. PilQ subfamily.
     
 0.917
comB
Competence protein B (comB); Involved in transformation (competence for DNA uptake).
     
 0.913
comC
Competence protein C (comC); Involved in transformation (competence for DNA uptake).
     
 0.887
comF
Competence protein F (comF); Involved in transformation (competence for DNA uptake).
     
 0.813
comA
Competence protein A (comA); Involved in transformation (competence for DNA uptake).
       0.808
nfuA
orfG protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.
       0.564
mrcA
Penicillin-binding protein 1A (ponA); Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits).
       0.548
comM
Competence protein (comM); Induced during competence development. Not needed for DNA uptake. May be involved in a recombination step.
      
 0.449
nudC
Conserved hypothetical protein; Similar to SP:P32664 PID:396335 GB:U00096 PID:1790429 percent identity: 47.29; identified by sequence similarity; putative.
       0.435
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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