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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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experimentally determined
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[Homology]
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hisDHistidinol dehydrogenase (hisD); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (427 aa)    
Predicted Functional Partners:
hisB
Imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (hisB); Similar to SP:P06987 GB:X03416 PID:41696 PID:41711 GB:U00096 percent identity: 64.97; identified by sequence similarity; putative; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
 
 0.999
hisI
phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase (hisIE); Similar to SP:P06989 GB:D43637 GB:U02072 GB:X03974 PID:41700 percent identity: 61.22; identified by sequence similarity; putative; In the C-terminal section; belongs to the PRA-PH family.
 
 
 0.999
hisG
ATP phosphoribosyltransferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
 
 0.998
hisC1
Histidinol-phosphate aminotransferase (hisC); Similar to SP:P06986 GB:U02071 GB:X03416 PID:41695 PID:41710 percent identity: 60.40; identified by sequence similarity; putative; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
 0.998
hisF
hisF cyclase (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
 
 0.998
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Similar to SP:P10371 PID:41713 GB:U00096 PID:1736702 PID:1736711 percent identity: 62.86; identified by sequence similarity; putative.
 
 
 0.993
hisH
Amidotransferase (hisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
 
 
 0.992
hisC2
Histidinol-phosphate aminotransferase (hisH); Similar to SP:P17731 PID:143814 GB:AL009126 percent identity: 38.70; identified by sequence similarity; putative; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
 0.983
thrA
Aspartokinase I / homoserine dehydrogenase I (thrA); Similar to SP:P00561 GB:M10644 GB:V00360 GB:V00361 PID:147979 percent identity: 62.21; identified by sequence similarity; putative; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
  
 0.806
trpC
Indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpC); Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity).
  
  
 0.712
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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