STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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hisFhisF cyclase (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). (258 aa)    
Predicted Functional Partners:
hisB
Imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (hisB); Similar to SP:P06987 GB:X03416 PID:41696 PID:41711 GB:U00096 percent identity: 64.97; identified by sequence similarity; putative; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
 
 
 0.999
hisH
Amidotransferase (hisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
 0.999
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Similar to SP:P10371 PID:41713 GB:U00096 PID:1736702 PID:1736711 percent identity: 62.86; identified by sequence similarity; putative.
 
0.999
hisI
phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase (hisIE); Similar to SP:P06989 GB:D43637 GB:U02072 GB:X03974 PID:41700 percent identity: 61.22; identified by sequence similarity; putative; In the C-terminal section; belongs to the PRA-PH family.
 
 0.999
hisD
Histidinol dehydrogenase (hisD); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
 0.998
hisG
ATP phosphoribosyltransferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
 
 0.993
hisC1
Histidinol-phosphate aminotransferase (hisC); Similar to SP:P06986 GB:U02071 GB:X03416 PID:41695 PID:41710 percent identity: 60.40; identified by sequence similarity; putative; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
 
 0.974
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase (purH); Similar to SP:P15639 GB:J05126 GB:X51950 PID:147420 PID:396345 percent identity: 77.19; identified by sequence similarity; putative.
  
 
 0.944
apt
Adenine phosphoribosyltransferase (apt); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
   
 
 0.931
purB
Adenylosuccinate lyase (purB); Similar to GB:M74924 SP:P25739 PID:145203 PID:42585 GB:U00096 percent identity: 76.97; identified by sequence similarity; putative.
    
 0.926
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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