STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tyrP-ATyrosine-specific transport protein (tyrP); Involved in transporting tyrosine across the cytoplasmic membrane; Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily. (400 aa)    
Predicted Functional Partners:
HI_0476
Predicted coding region HI0476; Hypothetical protein; identified by GeneMark; putative.
       0.675
HI_1394
Conserved hypothetical protein; Similar to PID:887850 GB:U00096 SP:Q46828 PID:1789267 percent identity: 68.32; identified by sequence similarity; putative; Belongs to the UPF0267 family.
  
     0.646
menC
O-succinylbenzoate-CoA synthase (menC); Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
  
     0.585
kdkA
Predicted coding region HI0260.1; Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D- manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position. To a lesser extent, can use GTP instead of ATP as substrate.
    
 0.562
HI_0108
Conserved hypothetical protein; Similar to GB:U14003 SP:P39402 PID:537207 GB:U00096 PID:1790826 percent identity: 39.25; identified by sequence similarity; putative.
  
     0.497
dnaJ
Heat shock protein (dnaJ); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ [...]
   
 
 0.496
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Similar to SP:P10371 PID:41713 GB:U00096 PID:1736702 PID:1736711 percent identity: 62.86; identified by sequence similarity; putative.
       0.487
hisF
hisF cyclase (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
       0.487
hisI
phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase (hisIE); Similar to SP:P06989 GB:D43637 GB:U02072 GB:X03974 PID:41700 percent identity: 61.22; identified by sequence similarity; putative; In the C-terminal section; belongs to the PRA-PH family.
       0.487
HI_0878
Conserved hypothetical protein; Similar to SP:P28636 PID:216638 PID:606122 GB:U00096 PID:1789575 percent identity: 49.34; identified by sequence similarity; putative.
  
     0.462
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.