Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ureGUrease accessory protein (ureG); Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG. (225 aa)    
Predicted Functional Partners:
ureF
Urease accessory protein (ureF); Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
 
 
 0.988
ureD
Urease accessory protein (ureH); Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
 
 
 0.986
ureE
Urease accessory protein (ureE); Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. Belongs to the UreE family.
 
 
 0.974
ureB
Urease, beta subunit (ureB); Similar to GB:L03307 SP:Q03283 PID:148153 percent identity: 61.76; identified by sequence similarity; putative; Belongs to the urease beta subunit family.
 
  
 0.953
ureC
Urease, alpha subunit (ureC); Similar to SP:Q07397 PID:216362 percent identity: 67.25; identified by sequence similarity; putative; Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
 
  
 0.950
slyD
Peptidyl-prolyl cis-trans isomerase, FkbP-type (slyD); Folding helper with both chaperone and peptidyl-prolyl cis- trans isomerase (PPIase) activities. Chaperone activity prevents aggregation of unfolded or partially folded proteins and promotes their correct folding. PPIases catalyze the cis-trans isomerization of Xaa- Pro bonds of peptides, which accelerates slow steps of protein folding and thus shortens the lifetime of intermediates. Both strategies lower the concentration of intermediates and increase the productivity and yield of the folding reaction (By similarity); Belongs to t [...]
    
 
 0.905
ureA
Urease, gamma subunit (ureA); Similar to SP:Q07399 PID:216360 percent identity: 67.00; identified by sequence similarity; putative; Belongs to the urease gamma subunit family.
 
  
 0.889
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
Server load: medium (48%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.