STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PGdxMembrane protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; In the C-terminal section; belongs to the glutaredoxin family. (241 aa)    
Predicted Functional Partners:
nrdA
Ribonucleoside-diphosphate reductase, alpha chain (nrdA); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
  
 0.894
msrAB
Peptide methionine sulfoxide reductase (msrA); Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
  
 
 0.887
gor
Glutathione reductase (gor); Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
 
 0.885
lpdA
Dihydrolipoamide dehydrogenase (lpdA); Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
  
 0.848
sspA
Stringent starvation protein A (sspA); Forms an equimolar complex with the RNA polymerase holoenzyme (RNAP) but not with the core enzyme.
  
 0.842
nrfX
Thiol:disulfide interchange protein (dsbE); Could be involved in disulfide bond formation. Could catalyzes a late, reductive step in the assembly of periplasmic NrfA c- type cytochrome, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase; Belongs to the thioredoxin family. DsbE subfamily.
   
 0.821
dsbE
Thiol:disulfide interchange protein (dsbE); Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity); Belongs to the thioredoxin family. DsbE subfamily.
   
 0.821
HI_1115
Thioredoxin, putative; Similar to PID:1213065 SP:P52229 percent identity: 36.36; identified by sequence similarity; putative.
   
 0.821
HI_1453
Conserved hypothetical protein; Similar to GB:AL009126 percent identity: 30.84; identified by sequence similarity; putative; Belongs to the thioredoxin family.
   
 0.821
rimK
Ribosomal protein S6 modification protein (rimK); Similar to SP:P17116 GB:X15859 PID:42747 GB:U00096 PID:1651386 percent identity: 45.55; identified by sequence similarity; putative.
    
 0.812
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.