Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
HI_0589Sigma factor regulatory protein, putative; Similar to SP:P46187 PID:987645 PID:1045631 PID:1050877 GB:U00096 percent identity: 29.01; identified by sequence similarity; putative. (139 aa)    
Predicted Functional Partners:
rseB
sigma-E factor regulatory protein (rseB); Negatively modulates the activity of sigma-E (RpoE) by stabilizing RseA under non-stress conditions. Although not essential for association of sigma-E with Rsea it increases their affinity 2- to 3-fold. When bound to RseA it prevents proteolysis by DegS, which is probably relieved by lipopolysaccharide binding (LPS) (By similarity). Belongs to the RseB family.
 
  
 0.899
rseA
sigma-E factor negative regulatory protein (mclA); An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytopl [...]
 
  
 0.684
sprT
Sprt protein (sprT); Similar to SP:P39902 PID:1208420 PID:882473 GB:U00096 PID:1789313 percent identity: 46.00; identified by sequence similarity; putative; Belongs to the SprT family.
  
     0.536
HI_0389
Outer membrane protein; Similar to GB:U00039 SP:P37194 GB:L23635 PID:387932 PID:466643 percent identity: 27.33; identified by sequence similarity; putative.
  
     0.529
HI_0162
Lipoprotein, putative; Similar to GB:U00096 PID:1773118 PID:1786637 percent identity: 25.82; identified by sequence similarity; putative.
  
     0.517
HI_1256
Predicted coding region HI1256; Hypothetical protein; identified by GeneMark; putative.
  
     0.515
lolB
hemM protein (hemM); Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
  
     0.514
HI_1459
Sigma factor, putative; Similar to GB:AL009126 percent identity: 26.75; identified by sequence similarity; putative; Belongs to the sigma-70 factor family. ECF subfamily.
  
  
 0.505
HI_1543
Conserved hypothetical protein; Similar to GB:U00096 SP:P75915 PID:1787272 percent identity: 39.78; identified by sequence similarity; putative; Belongs to the TorD/DmsD family.
  
     0.505
holD
DNA polymerase III, psi subunit (holD); DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown (By similarity).
  
     0.502
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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