Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cysESerine acetyltransferase (cysE); Similar to SP:P05796 GB:M15745 GB:M34333 PID:145676 PID:145694 percent identity: 73.05; identified by sequence similarity; putative. (267 aa)    
Predicted Functional Partners:
cysK
Cysteine synthetase (cysK); Similar to GB:M21451 SP:P11096 GB:X12615 PID:145686 PID:41201 percent identity: 70.65; identified by sequence similarity; putative; Belongs to the cysteine synthase/cystathionine beta- synthase family.
 
 0.999
thrA
Aspartokinase I / homoserine dehydrogenase I (thrA); Similar to SP:P00561 GB:M10644 GB:V00360 GB:V00361 PID:147979 percent identity: 62.21; identified by sequence similarity; putative; In the C-terminal section; belongs to the homoserine dehydrogenase family.
    
 0.958
sdaA
L-serine deaminase (sdaA); Similar to GB:M28695 SP:P16095 PID:290464 GB:U00096 PID:1736451 percent identity: 68.79; identified by sequence similarity; putative.
     
 0.936
serB
Phosphoserine phosphatase (serB); Catalyzes the dephosphorylation of phosphoserine (P-Ser).
    
 0.936
cysS
cysteinyl-tRNA synthetase (cysS); Similar to GB:M59381 SP:P21888 GB:X56234 GB:X59293 PID:145692 percent identity: 75.65; identified by sequence similarity; putative; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
  
 0.935
ilvA
Threonine deaminase (ilvA); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity).
  
  
 0.935
glyA
Serine hydroxymethyltransferase (serine methylase) (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.933
thrB
Homoserine kinase (thrB); Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
     
 0.925
pssA
Phosphatidylserine synthase (pssA); Similar to GB:M58699 SP:P23830 PID:147389 GB:U00096 PID:1788940 percent identity: 50.33; identified by sequence similarity; putative.
     
  0.920
trpB
Tryptophan synthase beta subunit (trpB); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
  0.920
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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