node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
adk | purA | HI_0349 | HI_1633 | Adenylate kinase (adk); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). It may be linked to the biosynthesis of lipopolysaccharide surface molecules, which are important for the pathogenesis of H.influenzae. Belongs to the adenylate kinase family. | Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.702 |
adk | purB | HI_0349 | HI_0639 | Adenylate kinase (adk); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). It may be linked to the biosynthesis of lipopolysaccharide surface molecules, which are important for the pathogenesis of H.influenzae. Belongs to the adenylate kinase family. | Adenylosuccinate lyase (purB); Similar to GB:M74924 SP:P25739 PID:145203 PID:42585 GB:U00096 percent identity: 76.97; identified by sequence similarity; putative. | 0.888 |
adk | purH | HI_0349 | HI_0887 | Adenylate kinase (adk); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). It may be linked to the biosynthesis of lipopolysaccharide surface molecules, which are important for the pathogenesis of H.influenzae. Belongs to the adenylate kinase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase (purH); Similar to SP:P15639 GB:J05126 GB:X51950 PID:147420 PID:396345 percent identity: 77.19; identified by sequence similarity; putative. | 0.691 |
purA | adk | HI_1633 | HI_0349 | Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Adenylate kinase (adk); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). It may be linked to the biosynthesis of lipopolysaccharide surface molecules, which are important for the pathogenesis of H.influenzae. Belongs to the adenylate kinase family. | 0.702 |
purA | purB | HI_1633 | HI_0639 | Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Adenylosuccinate lyase (purB); Similar to GB:M74924 SP:P25739 PID:145203 PID:42585 GB:U00096 percent identity: 76.97; identified by sequence similarity; putative. | 0.970 |
purA | purC | HI_1633 | HI_1726 | Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC); Similar to PID:1144522 SP:Q59566 PID:1550658 percent identity: 46.67; identified by sequence similarity; putative; Belongs to the SAICAR synthetase family. | 0.804 |
purA | purD | HI_1633 | HI_0888 | Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Phosphoribosylamine--glycine ligase (purD); Similar to SP:P15640 GB:J05126 GB:X51950 PID:147421 PID:396344 percent identity: 75.18; identified by sequence similarity; putative. | 0.732 |
purA | purE | HI_1633 | HI_1615 | Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit (purE); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.727 |
purA | purF | HI_1633 | HI_1207 | Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Amidophosphoribosyltransferase (purF); Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.794 |
purA | purH | HI_1633 | HI_0887 | Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase (purH); Similar to SP:P15639 GB:J05126 GB:X51950 PID:147420 PID:396345 percent identity: 77.19; identified by sequence similarity; putative. | 0.884 |
purA | purK | HI_1633 | HI_1616 | Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Phosphoribosylaminoimidazole carboxylase, ATPase subunit (purK); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family. | 0.639 |
purA | purL | HI_1633 | HI_0752 | Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Phosphoribosylformylglycinamidine synthase (purL); Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.973 |
purA | purN | HI_1633 | HI_1428 | Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Phosphoribosylglycinamide formyltransferase (purN); Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.644 |
purB | adk | HI_0639 | HI_0349 | Adenylosuccinate lyase (purB); Similar to GB:M74924 SP:P25739 PID:145203 PID:42585 GB:U00096 percent identity: 76.97; identified by sequence similarity; putative. | Adenylate kinase (adk); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). It may be linked to the biosynthesis of lipopolysaccharide surface molecules, which are important for the pathogenesis of H.influenzae. Belongs to the adenylate kinase family. | 0.888 |
purB | purA | HI_0639 | HI_1633 | Adenylosuccinate lyase (purB); Similar to GB:M74924 SP:P25739 PID:145203 PID:42585 GB:U00096 percent identity: 76.97; identified by sequence similarity; putative. | Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.970 |
purB | purC | HI_0639 | HI_1726 | Adenylosuccinate lyase (purB); Similar to GB:M74924 SP:P25739 PID:145203 PID:42585 GB:U00096 percent identity: 76.97; identified by sequence similarity; putative. | Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC); Similar to PID:1144522 SP:Q59566 PID:1550658 percent identity: 46.67; identified by sequence similarity; putative; Belongs to the SAICAR synthetase family. | 0.979 |
purB | purD | HI_0639 | HI_0888 | Adenylosuccinate lyase (purB); Similar to GB:M74924 SP:P25739 PID:145203 PID:42585 GB:U00096 percent identity: 76.97; identified by sequence similarity; putative. | Phosphoribosylamine--glycine ligase (purD); Similar to SP:P15640 GB:J05126 GB:X51950 PID:147421 PID:396344 percent identity: 75.18; identified by sequence similarity; putative. | 0.953 |
purB | purE | HI_0639 | HI_1615 | Adenylosuccinate lyase (purB); Similar to GB:M74924 SP:P25739 PID:145203 PID:42585 GB:U00096 percent identity: 76.97; identified by sequence similarity; putative. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit (purE); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.947 |
purB | purF | HI_0639 | HI_1207 | Adenylosuccinate lyase (purB); Similar to GB:M74924 SP:P25739 PID:145203 PID:42585 GB:U00096 percent identity: 76.97; identified by sequence similarity; putative. | Amidophosphoribosyltransferase (purF); Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.913 |
purB | purH | HI_0639 | HI_0887 | Adenylosuccinate lyase (purB); Similar to GB:M74924 SP:P25739 PID:145203 PID:42585 GB:U00096 percent identity: 76.97; identified by sequence similarity; putative. | Phosphoribosylaminoimidazolecarboxamide formyltransferase (purH); Similar to SP:P15639 GB:J05126 GB:X51950 PID:147420 PID:396345 percent identity: 77.19; identified by sequence similarity; putative. | 0.974 |