node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HI_0656.1 | aroE | HI_0656.1 | HI_0655 | Conserved hypothetical protein; Similar to SP:P45771 PID:606217 GB:U00096 PID:1789677 percent identity: 48.32; identified by sequence similarity; putative; To E.coli YrdD. | Shikimate 5-dehydrogenase (aroE); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.748 |
HI_0656.1 | polA | HI_0656.1 | HI_0856 | Conserved hypothetical protein; Similar to SP:P45771 PID:606217 GB:U00096 PID:1789677 percent identity: 48.32; identified by sequence similarity; putative; To E.coli YrdD. | DNA polymerase I (polA); In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | 0.440 |
HI_0656.1 | tag | HI_0656.1 | HI_0654 | Conserved hypothetical protein; Similar to SP:P45771 PID:606217 GB:U00096 PID:1789677 percent identity: 48.32; identified by sequence similarity; putative; To E.coli YrdD. | DNA-3-methyladenine glycosidase I (tagI); Hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine from the damaged DNA polymer formed by alkylation lesions. | 0.825 |
HI_0656.1 | topB | HI_0656.1 | HI_0444 | Conserved hypothetical protein; Similar to SP:P45771 PID:606217 GB:U00096 PID:1789677 percent identity: 48.32; identified by sequence similarity; putative; To E.coli YrdD. | DNA topoisomerase III (topB); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing [...] | 0.669 |
HI_0656.1 | tsaC | HI_0656.1 | HI_0656 | Conserved hypothetical protein; Similar to SP:P45771 PID:606217 GB:U00096 PID:1789677 percent identity: 48.32; identified by sequence similarity; putative; To E.coli YrdD. | Conserved hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. | 0.767 |
HI_0656.1 | yheS | HI_0656.1 | HI_0658 | Conserved hypothetical protein; Similar to SP:P45771 PID:606217 GB:U00096 PID:1789677 percent identity: 48.32; identified by sequence similarity; putative; To E.coli YrdD. | ABC transporter, ATP-binding protein; Genetic data indicate it may be involved in ribosome assembly or function. | 0.773 |
aroE | HI_0656.1 | HI_0655 | HI_0656.1 | Shikimate 5-dehydrogenase (aroE); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Conserved hypothetical protein; Similar to SP:P45771 PID:606217 GB:U00096 PID:1789677 percent identity: 48.32; identified by sequence similarity; putative; To E.coli YrdD. | 0.748 |
aroE | tag | HI_0655 | HI_0654 | Shikimate 5-dehydrogenase (aroE); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | DNA-3-methyladenine glycosidase I (tagI); Hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine from the damaged DNA polymer formed by alkylation lesions. | 0.779 |
aroE | tsaC | HI_0655 | HI_0656 | Shikimate 5-dehydrogenase (aroE); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Conserved hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. | 0.799 |
aroE | yheS | HI_0655 | HI_0658 | Shikimate 5-dehydrogenase (aroE); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | ABC transporter, ATP-binding protein; Genetic data indicate it may be involved in ribosome assembly or function. | 0.743 |
def | fmt | HI_0622 | HI_0623 | Polypeptide deformylase (def); Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity). | methionyl-tRNA formyltransferase (fmt); Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.987 |
def | recX | HI_0622 | HI_0599 | Polypeptide deformylase (def); Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity). | Regulatory protein (recX); Modulates RecA activity; Belongs to the RecX family. | 0.416 |
def | tag | HI_0622 | HI_0654 | Polypeptide deformylase (def); Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity). | DNA-3-methyladenine glycosidase I (tagI); Hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine from the damaged DNA polymer formed by alkylation lesions. | 0.562 |
def | topB | HI_0622 | HI_0444 | Polypeptide deformylase (def); Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity). | DNA topoisomerase III (topB); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing [...] | 0.561 |
fmt | def | HI_0623 | HI_0622 | methionyl-tRNA formyltransferase (fmt); Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Polypeptide deformylase (def); Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity). | 0.987 |
fmt | tag | HI_0623 | HI_0654 | methionyl-tRNA formyltransferase (fmt); Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | DNA-3-methyladenine glycosidase I (tagI); Hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine from the damaged DNA polymer formed by alkylation lesions. | 0.557 |
fmt | topB | HI_0623 | HI_0444 | methionyl-tRNA formyltransferase (fmt); Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | DNA topoisomerase III (topB); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing [...] | 0.564 |
ogt | polA | HI_0402 | HI_0856 | methylated-DNA--protein-cysteine methyltransferase (dat1); Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | DNA polymerase I (polA); In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | 0.546 |
ogt | tag | HI_0402 | HI_0654 | methylated-DNA--protein-cysteine methyltransferase (dat1); Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | DNA-3-methyladenine glycosidase I (tagI); Hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine from the damaged DNA polymer formed by alkylation lesions. | 0.755 |
polA | HI_0656.1 | HI_0856 | HI_0656.1 | DNA polymerase I (polA); In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | Conserved hypothetical protein; Similar to SP:P45771 PID:606217 GB:U00096 PID:1789677 percent identity: 48.32; identified by sequence similarity; putative; To E.coli YrdD. | 0.440 |