STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
tpiATriosephosphate isomerase (tpiA); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (263 aa)    
Predicted Functional Partners:
gapA
Glyceraldehyde-3-phosphate dehydrogenase (gapdH); Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
 0.999
pgk
Phosphoglycerate kinase (pgk); Similar to SP:P11665 PID:41422 PID:882455 GB:U00096 PID:1789294 percent identity: 81.14; identified by sequence similarity; putative; Belongs to the phosphoglycerate kinase family.
 0.999
pgi
Glucose-6-phosphate isomerase (pgi); Similar to SP:P11537 GB:X15196 PID:396360 PID:42377 GB:U00096 percent identity: 77.05; identified by sequence similarity; putative.
  
 0.995
fba
Fructose-bisphosphate aldolase (fba); Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
  
 0.994
eno
Enolase (eno); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
  
 
 0.985
tal
Transaldolase B (talB); Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
  
 0.978
tktA
Transketolase 1 (tktA); Catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing xylulose-5-phosphate and ribose-5-phosphate. Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate (By similarity).
  
 0.977
zwf
Glucose-6-phosphate 1-dehydrogenase (zwf); Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone.
   
 
 0.953
deoC
Deoxyribose-phosphate aldolase (deoC); Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
  
 0.946
eda
4-hydroxy-2-oxoglutarate aldolase/2-deydro-3-deoxyphosphogluconate aldolase (eda); Similar to GB:L20897 GB:M87458 GB:X63694 GB:X68871 PID:145827 percent identity: 37.31; identified by sequence similarity; putative; Belongs to the KHG/KDPG aldolase family.
     
 0.936
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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