Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
yafQConserved hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Its cognate antitoxin is RelB (By similarity). (102 aa)    
Predicted Functional Partners:
relB
Predicted coding region HI0710; Antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is YafQ (By similarity).
  
 
 0.986
parE
Topoisomerase IV, subunit B (parE); Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily.
      
 0.483
HI_0659
Predicted coding region HI0659; Hypothetical protein; identified by GeneMark; putative.
  
   
 0.460
vapC1
Virulence associated protein C, putative; Toxic component of a type II toxin-antitoxin (TA) system. Acts as an RNase, its toxic effect is neutralized by VapB1 antitoxin (By similarity); Belongs to the PINc/VapC protein family.
  
   
 0.448
vapD
Virulence associated protein D (vapD); Cleaves ssRNA, mostly between U:A; Belongs to the VapD ribonuclease family.
      
 0.444
selA
L-seryl-tRNA selenium transferase (selA); Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
       0.431
selB
Selenocysteine-specific elongation factor (selB); Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. SelB subfamily.
       0.431
HI_0660
Predicted coding region HI0660; Hypothetical protein; identified by GeneMark; putative.
 
   
 0.424
HI_0977
Cell filamentation protein (fic); Probable adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins.
  
     0.416
lexA
lexA repressor (lexA); Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
      
 0.406
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.